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. 2025 Apr:77:101185.
doi: 10.1016/j.yfrne.2025.101185. Epub 2025 Feb 18.

Maternal brain plasticity, physiology and exercise science: A scoping narrative review

Catherine M E Barrett  1 , Zohreh Zeidy  1 , Alison Farrell  2 , Lindsay S Cahill  3 , Katie P Wadden  4
Affiliations
Free article

Maternal brain plasticity, physiology and exercise science: A scoping narrative review

Catherine M E Barrett et al. Front Neuroendocrinol. 2025 Apr.
Free article

Abstract

Introduction: The perinatal period is characterized by extreme shifts in hormones, neurochemistry, and life experiences that drive significant changes in the brain, known as maternal plasticity. Due to rising maternal health conditions, such as postpartum depression, there is a critical need to investigate factors, such as engagement in physical activity and exercise, that may mitigate susceptibility to maladaptive maternal plasticity. This scoping review aims to analyze exercise interventions and maternal brain outcomes during reproduction.

Methods: A systematic search was completed in Medline, Embase, CINAHL, PsycINFO, SportDiscuss. The key concepts of the search were (i) brain plasticity, (ii) maternal reproductive period including pre-conception, pregnancy, and postpartum, and (iii) exercise interventions. Due to the limited amount of evidence available on this topic, the review findings were discussed using a combined scoping and narrative review approach.

Results: The search produced 2,167 unique articles after removing 2588 duplicates. Covidence software was used for the screening procedure. Following title and abstract screening, 2160 articles were deemed irrelevant and removed. Seven articles moved forward to full-text screening. One article was excluded during full-text screening for wrong outcomes, leaving six papers for extraction. Extraction revealed that four out of six studies were conducted in the rodent alone, one was conducted in humans alone and one was conducted in both a human and a rodent model.

Discussion: The methodological inconsistencies in the limited number of studies within this field highlight the need for standardization, which motivated the development of the Consensus on Exercise Reporting Template for animal research. Moreover, the present review highlights future directions and knowledge gaps, emphasizing the critical need for high-quality research to address the many unanswered questions regarding the impact of exercise on the maternal brain.

Keywords: Exercise; Maternal Health; Plasticity; Reproduction.

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