Polygenic Risk Scores for CKD Among an Ethnically Diverse Cohort of People With HIV

Won Jun Lee¹, Deirdre Sawinski², Paul MacLennan³, Haoxiang Cheng¹, Samreen Zafer¹, Robin M Nance⁴, Joseph A Delaney⁵, Bridget M Whitney⁵, Sonia Napravnik⁶, Edward R Cachay⁷, Laura Bamford⁷, Peter W Hunt⁸, Jeffrey M Jacobson⁹, Richard D Moore¹⁰, Jeanne Keruly¹⁰, Mari M Kitahata¹¹, Kenneth H Mayer¹², Michael S Saag³, Girish Nadkarni¹³, Heidi M Crane¹¹, Ke Hao¹, Nicole F Pelletier³, Paola Nicoletti¹, Jayme E Locke³, Inga Peter¹⁴

Affiliations

¹ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
² Weill Cornell School of Medicine, New York, New York.
³ Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
⁴ Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁵ Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
⁶ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
⁷ Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, California.
⁸ Division of Experimental Medicine, University of California San Francisco, San Francisco, California.
⁹ Center for AIDS Research, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio.
¹⁰ Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
¹¹ Department of Medicine, University of Washington School of Medicine, Seattle, Washington; Center for AIDS Research, University of Washington, Seattle, Washington.
¹² The Fenway Institute at Fenway Health, Boston, Massachusetts.
¹³ Department of Medicine, the Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
¹⁴ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: inga.peter@mssm.edu.

PMID: 39978721
PMCID: PMC12439483 (available on 2026-02-18)
DOI: 10.1053/j.ajkd.2024.11.019

Polygenic Risk Scores for CKD Among an Ethnically Diverse Cohort of People With HIV

Won Jun Lee et al. Am J Kidney Dis. 2025 Jun.

. 2025 Jun;85(6):799-802.

doi: 10.1053/j.ajkd.2024.11.019. Epub 2025 Feb 18.

Authors

Affiliations

¹ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
² Weill Cornell School of Medicine, New York, New York.
³ Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
⁴ Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁵ Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
⁶ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
⁷ Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, California.
⁸ Division of Experimental Medicine, University of California San Francisco, San Francisco, California.
⁹ Center for AIDS Research, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio.
¹⁰ Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
¹¹ Department of Medicine, University of Washington School of Medicine, Seattle, Washington; Center for AIDS Research, University of Washington, Seattle, Washington.
¹² The Fenway Institute at Fenway Health, Boston, Massachusetts.
¹³ Department of Medicine, the Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
¹⁴ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: inga.peter@mssm.edu.

PMID: 39978721
PMCID: PMC12439483 (available on 2026-02-18)
DOI: 10.1053/j.ajkd.2024.11.019

No abstract available

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Conflict of interest statement

The remaining authors declare that they have no relevant financial interests.

References

1. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl. 2022;12(1):7–11. doi: 10.1016/j.kisu.2021.11.003 - DOI - PMC - PubMed
1. Bertoldi A, De Crignis E, Miserocchi A, et al. HIV and kidney: a dangerous liaison. New Microbiol. 2017;40(1):1–10. - PubMed
1. Swanepoel CR, Atta MG, D'Agati VD, et al. Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. Mar 2018;93(3):545–559. doi: 10.1016/j.kint.2017.11.007 - DOI - PMC - PubMed
1. Abraham AG, Althoff KN, Jing Y, et al. End-stage renal disease among HIV-infected adults in North America. Clin Infect Dis. Mar 15 2015;60(6):941–9. doi: 10.1093/cid/ciu919 - DOI - PMC - PubMed
1. Shelton BA, Sawinski D, Peter I, et al. African American/Black race, apolipoprotein L1 , and serum creatinine among persons with HIV. AIDS. Dec 1 2023;37(15):2349–2357. doi: 10.1097/QAD.0000000000003708 - DOI - PMC - PubMed

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Polygenic Risk Scores for CKD Among an Ethnically Diverse Cohort of People With HIV

Affiliations

Polygenic Risk Scores for CKD Among an Ethnically Diverse Cohort of People With HIV

Authors

Affiliations

Conflict of interest statement

References

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