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Review
. 2025 Feb 7;60(2):185-190.
doi: 10.3760/cma.j.cn115330-20240425-00239.

[Progress in olfactory bulb lesions in olfactory dysfunction induced by nasal inflammatory diseases]

[Article in Chinese]
P Q Liu  1 , Y Xu  1
Affiliations
Review

[Progress in olfactory bulb lesions in olfactory dysfunction induced by nasal inflammatory diseases]

[Article in Chinese]
P Q Liu et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. .

Abstract

慢性鼻部炎症可导致嗅上皮和嗅感觉神经元受损，引发嗅觉障碍的发生。除此之外，嗅球病变在嗅觉障碍的发病机制中扮演着至关重要的角色。作为嗅觉系统的关键中继站，嗅球接收并处理来自嗅感觉神经元的嗅觉信息。慢性鼻部炎症的持续刺激可引发嗅球的萎缩及嗅觉关键蛋白的丢失，同时引发嗅球中神经胶质细胞和其他免疫细胞过度激活，导致炎性介质的释放。值得注意的是，新型冠状病毒相关鼻部炎性疾病已被观察到显著的嗅球损伤。基于此，本文综述了鼻部炎性疾病对嗅球病理生理特征和炎性损伤的影响，以及嗅球的修复对嗅觉的作用。.

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