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. 2025 Feb 20;15(1):63.
doi: 10.1038/s41398-025-03287-6.

Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population

Sarah M C Colbert  1   2   3 , Lauren Lepow  4   5 , Brian Fennessy  5 , Nakao Iwata  6 , Masashi Ikeda  6   7 , Takeo Saito  6 , Chikashi Terao  8   9   10 , Michael Preuss  5 , Jyotishman Pathak  11 , J John Mann  12   13   14 , Hilary Coon  15 , Niamh Mullins  16   4   5
Affiliations

Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population

Sarah M C Colbert et al. Transl Psychiatry. .

Abstract

Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development and progression are poorly understood. We used ICD codes and a natural language processing algorithm to identify individuals in a hospital biobank with SI-only, SB, and controls without either. We compared the profiles of SB and SI-only patients to controls, and each other, using phenome-wide association studies (PheWAS) and polygenic risk scores (PRS). PheWAS identified many risk factors for SB and SI-only, plus specific psychiatric disorders which may be involved in progression from SI-only to SB. PRS for suicide attempt were only associated with SB, and even after accounting for psychiatric disorder PRS. SI PRS were only associated with SI-only, although not after accounting for psychiatric disorder PRS. These findings advance understanding of distinct genetic and clinical risk factors for SB and SI-only, which will aid in early detection and intervention efforts.

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Conflict of interest statement

Competing interests: Dr. Mann receives royalties for commercial use of the C-SSRS from the Research Foundation for Mental Hygiene and from Columbia University for the Columbia Pathways App. The other authors have no conflicts of interest to declare. Ethics approval and consent to participate: All methods were performed in accordance with the relevant guidelines and regulations. Relevant study activities for the current report were approved by the Icahn School of Medicine at Mount Sinai Institutional Review Board (Institutional Review Board 07 0529) and all study participants provided written informed consent.

Figures

Fig. 1
Fig. 1. Comparison of sociodemographic and behavioral characteristics between individuals with and without different suicide outcomes.
Suicidal behavior (SB) cases and suicidal ideation (SI)-only cases were compared to determine their differences from controls and from each other. Values represent either means (for age) or percentages (for all others). Bonferroni-corrected significance threshold: p < 2.38 × 10−3. * indicates a statistically significant difference between two groups.
Fig. 2
Fig. 2. PheWAS of suicide outcomes in BioMe.
PheWAS results comparing (A) SB cases and controls in the upper plot and (B) SI-only cases and controls in the lower plot. Color filled boxes indicate phecodes that were also significantly associated in the comparison between SB cases and SI-only cases. Some significant associations are not labeled for legibility, but full results can be found in Supplementary Tables 6–8. The dashed lines on the y-axes indicate the Bonferroni-corrected significance thresholds: SB vs. controls p = 5.59 × 10−5 and SI-only vs. controls p = 5.63 × 10−5.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. Facts About Suicide. Available from: https://www.cdc.gov/suicide/facts. Accessed March 2024.
    1. Franklin JC, Ribeiro JD, Fox KR, Bentley KH, Kleiman EM, Huang X, et al. Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research. Psychol Bull. 2017;143:187–232. - PubMed
    1. Beautrais AL. Further suicidal behavior among medically serious suicide attempters. Suicide Life Threat Behav. 2004;34:1–11. - PubMed
    1. Suokas J, Suominen K, Isometsä E, Ostamo A, Lönnqvist J. Long-term risk factors for suicide mortality after attempted suicide–findings of a 14-year follow-up study. Acta Psychiatr Scand. 2001;104:117–21. - PubMed
    1. Nock MK, Borges G, Bromet EJ, Alonso J, Angermeyer M, Beautrais A, et al. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry. 2008;192:98–105. - PMC - PubMed

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