Physiological effects of nasal high flow therapy during exercise in patients with chronic obstructive pulmonary disease: A crossover randomised controlled trial

Tristan Bonnevie^{1

2}, Francis-Edouard Gravier^{1

2}, Pauline Smondack^{1

3}, Emeline Fresnel⁴, Isabelle Rivals^{5

6}, Helena Brunel⁷, Yann Combret^{8

9}, Clément Médrinal^{8

9}, Guillaume Prieur^{2

9

10}, Fairuz Boujibar^{11

12}, Thomas Similowski^{5

13}, Jean-François Muir^{1

2

14}, Antoine Cuvelier^{1

2

14}, Maxime Patout^{5

13}

Affiliations

¹ Association ADIR, Aide à domicile des patients insuffisants respiratoires, Rouen, France.
² Univ Rouen Normandie, Normandie Univ, Rouen, France.
³ Department of rehabilitation (P3R), Rouen Normandy University Hospital, Rouen, France.
⁴ KerNel Biomedical, Rouen, France.
⁵ Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
⁶ Equipe de Statistique Appliquée, ESPCI Paris, PSL Research University, Paris, France.
⁷ Saint-Michel School of Physiotherapy, Paris-Saclay University, Paris, France.
⁸ UVSQ, Erphan, Paris-Saclay University, Versailles, France.
⁹ Physiotherapy Department, Le Havre Hospital, Le Havre, France.
¹⁰ Institute of Research and Clinical Experimentation (IREC), Catholic University of Louvain, Brussels, Belgium.
¹¹ Department of Thoracic Surgery, Rouen University Hospital, Rouen, France.
¹² Haute Normandie Research and Biomedical Innovation, Normandie University, Rouen, France.
¹³ Site Pitié-Salpêtrière, Service des Pathologies du Sommeil (Département R3S), Groupe Hospitalier Universitaire APHP-Sorbonne Université, Paris, France.
¹⁴ Pulmonary, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital, Rouen, France.

Free article

Tristan Bonnevie et al. Pulmonology. 2025.

Free article

. 2025 Dec 31;31(1):2466922.

doi: 10.1080/25310429.2025.2466922. Epub 2025 Feb 21.

¹ Association ADIR, Aide à domicile des patients insuffisants respiratoires, Rouen, France.
² Univ Rouen Normandie, Normandie Univ, Rouen, France.
³ Department of rehabilitation (P3R), Rouen Normandy University Hospital, Rouen, France.
⁴ KerNel Biomedical, Rouen, France.
⁵ Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
⁶ Equipe de Statistique Appliquée, ESPCI Paris, PSL Research University, Paris, France.
⁷ Saint-Michel School of Physiotherapy, Paris-Saclay University, Paris, France.
⁸ UVSQ, Erphan, Paris-Saclay University, Versailles, France.
⁹ Physiotherapy Department, Le Havre Hospital, Le Havre, France.
¹⁰ Institute of Research and Clinical Experimentation (IREC), Catholic University of Louvain, Brussels, Belgium.
¹¹ Department of Thoracic Surgery, Rouen University Hospital, Rouen, France.
¹² Haute Normandie Research and Biomedical Innovation, Normandie University, Rouen, France.
¹³ Site Pitié-Salpêtrière, Service des Pathologies du Sommeil (Département R3S), Groupe Hospitalier Universitaire APHP-Sorbonne Université, Paris, France.
¹⁴ Pulmonary, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital, Rouen, France.

No abstract available

Keywords: Chronic obstructive pulmonary disease; constant workload exercise testing; pulmonary rehabilitation; work of breathing.

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