International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus

Emma Short^{1

2}, Robert T R Huckstepp³, Kambiz Alavian⁴, Winfried M K Amoaku⁵, Thomas M Barber^{6

7}, Edwin J R van Beek^{8

9}, Emyr Benbow¹⁰, Sunil Bhandari^{11

12}, Phillip Bloom¹³, Carlo Cota¹⁴, Paul Chazot¹⁵, Gary Christopher¹⁶, Marco Demaria^{17

18}, Jorge D Erusalimsky¹⁹, David A Ferenbach²⁰, Thomas Foster²¹, Gus Gazzard^{22

23}, Richard Glassock²⁴, Noordin Jamal²⁵, Raj Kalaria²⁶, Venkateswarlu Kanamarlapudi²⁷, Adnan H Khan²⁸, Yamini Krishna^{29

30}, Christiaan Leeuwenburgh³¹, Ian van der Linde³², Antonello Lorenzini^{33

34}, Andrea Britta Maier^{35

36}, Reinhold J Medina³⁰, Cecilia L Miotto³⁷, Abhik Mukherjee³⁸, Krishna Mukkanna³⁹, James T Murray²⁷, Alexander Nirenberg^{40

41}, Donald B Palmer⁴², Graham Pawelec^{43

44}, Venkat Reddy^{45

46}, Arianna Caroline Rosa⁴⁷, Andrew D Rule⁴⁸, Paul G Shiels⁴⁹, Carl Sheridan³⁰, Jeremy Tree⁵⁰, Dialechti Tsimpida⁵¹, Zoe C Venables^{52

53}, Jack Wellington⁵⁴, Stuart R G Calimport^{55

56}, Barry L Bentley^{55

56

57

58

59}

Affiliations

¹ Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK. EShort@cardiffmet.ac.uk.
² Department of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK. EShort@cardiffmet.ac.uk.
³ School of Life Sciences, University of Warwick, Coventry, UK.
⁴ Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
⁵ School of Medicine, University of Nottingham, Nottingham, UK.
⁶ Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, UK.
⁷ Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
⁸ Edinburgh Imaging Facility, Queen's Medical Research Institute, Edinburgh, UK.
⁹ NHS Lothian Health Board, Edinburgh, UK.
¹⁰ Manchester Medical School, University of Manchester, Manchester, UK.
¹¹ Hull Teaching Hospitals NHS Trust, Hull, UK.
¹² Hull York Medical School, Hull, UK.
¹³ Imperial College Healthcare NHS Trust, London, UK.
¹⁴ Genetic Research, Molecular Biology and Dermatopathology Unit, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
¹⁵ Durham University, Durham, UK.
¹⁶ Centre for Ageing and Dementia Research, Swansea University, Swansea, UK.
¹⁷ European Research Institute for the Biology of Ageing, Groningen, the Netherlands.
¹⁸ Institute for Mechanisms of Health, Ageing and Disease (MoHAD), University Medical Center Groningen, Groningen, the Netherlands.
¹⁹ The Cellular and Molecular Pathophysiology Group, Cardiff Metropolitan University, Cardiff, UK.
²⁰ Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
²¹ University of Florida, Gainesville, FL, USA.
²² Moorfields Eye Hospital NHS Foundation Trust, London, UK.
²³ UCL Institute of Ophthalmology, London, UK.
²⁴ Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
²⁵ University of East Anglia, Norwich, UK.
²⁶ Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
²⁷ Swansea University Medical School, Swansea University, Swansea, UK.
²⁸ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
²⁹ Liverpool Clinical Laboratories, National Specialist Ophthalmic Pathology Service, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
³⁰ Department of Eye and Vision Science, Institute of Life Course and Medical Science, University of Liverpool, Liverpool, UK.
³¹ Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
³² Cognition and Neuroscience Group, ARU Centre for Mind and Behaviour, Faculty of Science & Engineering, Anglia Ruskin University, Cambridge, UK.
³³ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³⁴ National Institute of Biosystems and Biostructures INBB, Rome, Italy.
³⁵ NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
³⁶ Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, the Netherlands.
³⁷ Cardiff and Vale University Health Board, Cardiff, UK.
³⁸ Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
³⁹ University Hospital of Wales, Cardiff, Wales, UK.
⁴⁰ Australasian College of Cutaneous Oncology, Docklands, Australia.
⁴¹ Dorevitch Pathology, Heidelberg West, Australia.
⁴² Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
⁴³ Department of Immunology, University of Tübingen, Tübingen, Germany.
⁴⁴ Health Sciences North Research Institute, Sudbury, ON, Canada.
⁴⁵ Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, UK.
⁴⁶ Department of Rheumatology, University College Hospital, London, UK.
⁴⁷ Department of Drug Science and Technology, University of Turin, Turin, Italy.
⁴⁸ Departments of Medicine and of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
⁴⁹ Glasgow Geroscience Group, School of Molecular Biosciences, MVLS, University of Glasgow, Glasgow, UK.
⁵⁰ Director of the Advanced Diagnostics and Medical Technologies Research Institute, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, UK.
⁵¹ Centre for Research On Ageing, Department of Gerontology, University of Southampton, Southampton, UK.
⁵² Norfolk and Norwich University Hospital, Norwich, UK.
⁵³ Norwich Medical School, Norwich, UK.
⁵⁴ Leeds Teaching Hospitals NHS Foundation Trust, Leeds, UK.
⁵⁵ Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
⁵⁶ Collaboration for the Advancement of Sustainable Medical Innovation (CASMI), University College London, London, UK.
⁵⁷ Center for Engineering in Medicine and Surgery, Harvard Medical School, Boston, MA, USA.
⁵⁸ Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵⁹ Shriners Children's, Boston, MA, USA.

PMID: 39982667
DOI: 10.1007/s11357-025-01509-9

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus

Emma Short et al. Geroscience. 2025.

. 2025 Feb 21.

doi: 10.1007/s11357-025-01509-9. Online ahead of print.

Authors

Affiliations

¹ Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK. EShort@cardiffmet.ac.uk.
² Department of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK. EShort@cardiffmet.ac.uk.
³ School of Life Sciences, University of Warwick, Coventry, UK.
⁴ Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
⁵ School of Medicine, University of Nottingham, Nottingham, UK.
⁶ Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, UK.
⁷ Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
⁸ Edinburgh Imaging Facility, Queen's Medical Research Institute, Edinburgh, UK.
⁹ NHS Lothian Health Board, Edinburgh, UK.
¹⁰ Manchester Medical School, University of Manchester, Manchester, UK.
¹¹ Hull Teaching Hospitals NHS Trust, Hull, UK.
¹² Hull York Medical School, Hull, UK.
¹³ Imperial College Healthcare NHS Trust, London, UK.
¹⁴ Genetic Research, Molecular Biology and Dermatopathology Unit, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
¹⁵ Durham University, Durham, UK.
¹⁶ Centre for Ageing and Dementia Research, Swansea University, Swansea, UK.
¹⁷ European Research Institute for the Biology of Ageing, Groningen, the Netherlands.
¹⁸ Institute for Mechanisms of Health, Ageing and Disease (MoHAD), University Medical Center Groningen, Groningen, the Netherlands.
¹⁹ The Cellular and Molecular Pathophysiology Group, Cardiff Metropolitan University, Cardiff, UK.
²⁰ Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
²¹ University of Florida, Gainesville, FL, USA.
²² Moorfields Eye Hospital NHS Foundation Trust, London, UK.
²³ UCL Institute of Ophthalmology, London, UK.
²⁴ Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
²⁵ University of East Anglia, Norwich, UK.
²⁶ Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
²⁷ Swansea University Medical School, Swansea University, Swansea, UK.
²⁸ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
²⁹ Liverpool Clinical Laboratories, National Specialist Ophthalmic Pathology Service, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
³⁰ Department of Eye and Vision Science, Institute of Life Course and Medical Science, University of Liverpool, Liverpool, UK.
³¹ Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
³² Cognition and Neuroscience Group, ARU Centre for Mind and Behaviour, Faculty of Science & Engineering, Anglia Ruskin University, Cambridge, UK.
³³ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³⁴ National Institute of Biosystems and Biostructures INBB, Rome, Italy.
³⁵ NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
³⁶ Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, the Netherlands.
³⁷ Cardiff and Vale University Health Board, Cardiff, UK.
³⁸ Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
³⁹ University Hospital of Wales, Cardiff, Wales, UK.
⁴⁰ Australasian College of Cutaneous Oncology, Docklands, Australia.
⁴¹ Dorevitch Pathology, Heidelberg West, Australia.
⁴² Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
⁴³ Department of Immunology, University of Tübingen, Tübingen, Germany.
⁴⁴ Health Sciences North Research Institute, Sudbury, ON, Canada.
⁴⁵ Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, UK.
⁴⁶ Department of Rheumatology, University College Hospital, London, UK.
⁴⁷ Department of Drug Science and Technology, University of Turin, Turin, Italy.
⁴⁸ Departments of Medicine and of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
⁴⁹ Glasgow Geroscience Group, School of Molecular Biosciences, MVLS, University of Glasgow, Glasgow, UK.
⁵⁰ Director of the Advanced Diagnostics and Medical Technologies Research Institute, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, UK.
⁵¹ Centre for Research On Ageing, Department of Gerontology, University of Southampton, Southampton, UK.
⁵² Norfolk and Norwich University Hospital, Norwich, UK.
⁵³ Norwich Medical School, Norwich, UK.
⁵⁴ Leeds Teaching Hospitals NHS Foundation Trust, Leeds, UK.
⁵⁵ Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
⁵⁶ Collaboration for the Advancement of Sustainable Medical Innovation (CASMI), University College London, London, UK.
⁵⁷ Center for Engineering in Medicine and Surgery, Harvard Medical School, Boston, MA, USA.
⁵⁸ Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵⁹ Shriners Children's, Boston, MA, USA.

PMID: 39982667
DOI: 10.1007/s11357-025-01509-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

1. Calimport SRG, Bentley BL. Aging classified as a cause of disease in ICD-11. Rejuvenation Res. 2019. https://doi.org/10.1089/rej.2019.2242 . - DOI - PubMed
1. Short E, ICCARP, Calimport S, Bentley B. Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. Geroscience. 2024. https://doi.org/10.1007/s11357-024-01315-9 . - DOI - PubMed
1. Di Micco R, Krizhanovsky V, Baker D, d’Adda di Fagagna F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 2021;22(2):75–95. https://doi.org/10.1038/s41580-020-00314-w . - DOI - PubMed
1. Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A. Role of p53 in the regulation of cellular senescence. Biomolecules. 2020;10(3):420. https://doi.org/10.3390/biom10030420 . - DOI - PubMed - PMC
1. Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021;374(6567):eabb3420. https://doi.org/10.1126/science.abb3420 . - DOI - PubMed - PMC

LinkOut - more resources

Full Text Sources
- Springer

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus

Affiliations

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus

Authors

Affiliations

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources