Indexing GFR Using Extracellular Volume versus Body Surface Area in a Population with Type 1 Diabetes and Diabetic Kidney Disease

Vikas S Sridhar¹, Luxcia Kugathasan¹, Leif Erik Lovblom^{2

3}, Ni Huajing¹, Sebastien O Lanctot⁴, David M Maahs⁵, Petter Bjornstad⁶, M Luiza Caramori⁷, Sylvia E Rosas⁸, Peter Rossing^{9

10}, Katherine R Tuttle^{11

12}, Rodica Pop-Busui¹³, Sarit Polsky¹⁴, Amy B Karger¹⁵, Chunyi Wu¹⁶, Andrzej T Galecki^{16

17}, Bruce A Perkins^{4

18}, Michael Mauer¹⁹, Alessandro Doria⁸, David Z I Cherney¹

Affiliations

¹ Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
² Biostatistics Department, University Health Network, Toronto, Ontario, Canada.
³ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
⁴ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
⁵ Division of Pediatric Endocrinology, Department of Pediatrics, Stanford University, Stanford, California.
⁶ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁷ Department of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio.
⁸ Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
⁹ Steno Diabetes Center Copenhagen, Herlev, Denmark.
¹⁰ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹¹ Providence Medical Research Center, Providence Inland Northwest Health, Spokane, Washington.
¹² Nephrology Division, Kidney Research Institute, University of Washington, Seattle, Washington.
¹³ Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
¹⁴ Departments of Medicine and Pediatrics, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
¹⁵ Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota.
¹⁶ Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
¹⁷ Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
¹⁸ Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota.

PMID: 39982799
PMCID: PMC12187243 (available on 2026-07-01)
DOI: 10.1681/ASN.0000000668

Indexing GFR Using Extracellular Volume versus Body Surface Area in a Population with Type 1 Diabetes and Diabetic Kidney Disease

Vikas S Sridhar et al. J Am Soc Nephrol. 2025.

. 2025 Feb 21;36(7):1414-1416.

doi: 10.1681/ASN.0000000668.

Authors

Affiliations

¹ Division of Nephrology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
² Biostatistics Department, University Health Network, Toronto, Ontario, Canada.
³ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
⁴ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
⁵ Division of Pediatric Endocrinology, Department of Pediatrics, Stanford University, Stanford, California.
⁶ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁷ Department of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio.
⁸ Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
⁹ Steno Diabetes Center Copenhagen, Herlev, Denmark.
¹⁰ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
¹¹ Providence Medical Research Center, Providence Inland Northwest Health, Spokane, Washington.
¹² Nephrology Division, Kidney Research Institute, University of Washington, Seattle, Washington.
¹³ Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
¹⁴ Departments of Medicine and Pediatrics, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
¹⁵ Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota.
¹⁶ Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
¹⁷ Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
¹⁸ Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota.

PMID: 39982799
PMCID: PMC12187243 (available on 2026-07-01)
DOI: 10.1681/ASN.0000000668

No abstract available

Keywords: GFR; diabetes mellitus; diabetic kidney disease.

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Conflict of interest statement

Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/JSN/F95.

References

1. Saran R Robinson B Abbott KC, et al. US renal data system 2017 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2018;71(3 suppl 1):A7. doi: 10.1053/j.ajkd.2018.01.002 - DOI - PMC - PubMed
1. Jodal L, Brochner-Mortensen J. Simplified methods for assessment of renal function as the ratio of glomerular filtration rate to extracellular fluid volume. Nucl Med Commun. 2012;33(12):1243–1253. doi: 10.1097/MNM.0b013e3283591908 - DOI - PubMed
1. Levey AS Stevens LA Schmid CH, et al.; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612. doi: 10.7326/0003-4819-150-9-200905050-00006 - DOI - PMC - PubMed
1. Bird NJ, Peters C, Michell AR, Peters AM. Reproducibilities and responses to food intake of GFR measured with chromium-51-EDTA and iohexol simultaneously and independently in normal subjects. Nephrol Dial Transplant. 2008;23(6):1902–1909. doi: 10.1093/ndt/gfm825 - DOI - PubMed
1. Peters AM Perry L Hooker CA, et al. Extracellular fluid volume and glomerular filtration rate in 1878 healthy potential renal transplant donors: effects of age, gender, obesity and scaling. Nephrol Dial Transplant. 2012;27(4):1429–1437. doi: 10.1093/ndt/gfr479 - DOI - PubMed

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Indexing GFR Using Extracellular Volume versus Body Surface Area in a Population with Type 1 Diabetes and Diabetic Kidney Disease

Affiliations

Indexing GFR Using Extracellular Volume versus Body Surface Area in a Population with Type 1 Diabetes and Diabetic Kidney Disease

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources