Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2025 Jul 30;29(2):201-210.
doi: 10.5935/1518-0557.20240095.

Predictors of Pregnancy after Artificial Insemination in Women with Polycystic Ovary Syndrome

Tânia Moreira  1 , Carla Leal  1   2   3   4 , Márcia Barreiro  1   2   3   4 , António Tomé  1   3 , Emídio Vale-Fernandes  1   2   3   4
Affiliations
Observational Study

Predictors of Pregnancy after Artificial Insemination in Women with Polycystic Ovary Syndrome

Tânia Moreira et al. JBRA Assist Reprod. .

Abstract

Objective: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, being one of the main causes of infertility. Anti-Müllerian hormone (AMH) is an important marker of ovarian reserve and has been proposed as an alternative criterion for the diagnosis of PCOS. This study verifies whether AMH and body mass index (BMI) values are predictors of pregnancy in infertile women with PCOS undergoing artificial insemination (AI), a less invasive and painless technique of assisted reproductive technologies (ART).

Methods: This retrospective observational study involved 220 women with PCOS who underwent AI between 2010 and 2022. Participants were categorized into three groups based on BMI and serum AMH levels. To categorize the three AMH classes, the 25th (4.08ng/mL) and 75th (8.99ng/mL) AMH percentiles were defined as cut-offs, and the words 'low', 'middle', and 'high' were utilized to define the groups.

Results: There was a tendency towards a decrease in reproductive outcomes (number of inseminations with positive human-chorionic gonadotropin, number of live births, and number of term births) with an increase in the BMI value. All of these outcomes were also slightly higher in women with 'middle' AMH levels compared to women with 'low' and 'high' AMH. However, none of these results were statistically significant.

Conclusions: This study suggests BMI may be an important predictive factor for pregnancy and there appears to be a range of biological normality for AMH values, where 'low' and 'high' levels of this hormone could constitute a marker of poor reproductive prognosis, in women with PCOS undergoing AI.

Keywords: anti-Müllerian hormone; artificial insemination; body mass index; intrauterine insemination; polycystic ovary syndrome; reproductive outcomes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Allahbadia GN. Intrauterine Insemination: Fundamentals Revisited. J Obstet Gynaecol India. 2017;67:385–392. doi: 10.1007/s13224-017-1060-x. - DOI - PMC - PubMed
    1. Alnakash AH, Al-Tae’e NK. Polycystic ovarian syndrome: The correlation between the LH/FSH ratio and disease manifestations. Middle East Fertil Soc J. 2007;12:35–40.
    1. Aydin Y, Hassa H, Oge T, Tokgoz VY. Factors predictive of clinical pregnancy in the first intrauterine insemination cycle of 306 couples with favourable female patient characteristics. Hum Fertil (Camb) 2013;16:286–290. doi: 10.3109/14647273.2013.841328. - DOI - PubMed
    1. Bayer SR, Alper MM, Penzias AS. The Boston IVF handbook of infertility: a practical guide for practitioners who care for infertile couples. 4th. San Diego: CRC Press, Taylor & Francis Group; 2018.
    1. Bertone-Johnson ER, Manson JE, Purdue-Smithe AC, Steiner AZ, Eliassen AH, Hankinson SE, Rosner BA, Whitcomb BW. Anti-Müllerian hormone levels and incidence of early natural menopause in a prospective study. Hum Reprod. 2018;33:1175–1182. doi: 10.1093/humrep/dey077. - DOI - PMC - PubMed

Publication types

Substances