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Review
. 2025 Apr;1871(4):167732.
doi: 10.1016/j.bbadis.2025.167732. Epub 2025 Feb 20.

A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy

M A Holborn  1 , J Mellet  1 , F Joubert  2 , D Ballot  3 , M S Pepper  4
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Free article
Review

A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy

M A Holborn et al. Biochim Biophys Acta Mol Basis Dis. 2025 Apr.
Free article

Abstract

Within the last decade, several studies have explored whether there might be a genetic component in hypoxic-ischaemic encephalopathy (HIE) that influences susceptibility to or outcomes following hypoxic-ischaemic injury. This review provides a comprehensive overview of the findings to date from published studies investigating the genetics of HIE. It also highlights some of the challenges faced by researchers, as well as recommendations for future research.

Keywords: Genetics; Genomics; Hypoxic-ischaemic encephalopathy; Variants.

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Conflict of interest statement

Declaration of competing interest The authors have no competing interests to declare.

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