adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

Jiawei Zhong¹, Danae Zareifi¹, Sophie Weinbrenner², Mattias Hansen¹, Felix Klingelhuber³, Pamela A Nono Nankam⁴, Scott Frendo-Cumbo¹, Nayanika Bhalla⁵, Lina Cordeddu¹, Thais de Castro Barbosa¹, Peter Arner¹, Ingrid Dahlman⁶, Maheswary Muniandy⁷, Sini Heinonen⁷, Kirsi H Pietiläinen⁸, Anne Hoffmann⁴, Adhideb Ghosh⁹, Dorit John¹⁰, Anke Tönjes¹¹, Patrik L Ståhl⁵, Yvonne Böttcher¹², Maria Keller¹³, Peter Kovacs¹⁴, Alastair G Kerr¹, Dominique Langin¹⁵, Christian Wolfrum⁹, Matthias Blüher¹³, Natalie Krahmer³, Lucas Massier¹⁶, Niklas Mejhert¹⁷, Mikael Rydén¹⁸

Affiliations

¹ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden.
² Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
³ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁴ Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
⁵ SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
⁶ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁷ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
⁸ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Healthy Weight Hub, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
⁹ Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
¹⁰ Medical Department II - Division of Oncology, Gastroenterology, Hepatology and Pneumology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹¹ Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹² Department of Clinical Molecular Biology, EpiGen, Institute of Clinical Medicine, University of Oslo, 1171 Oslo, Norway; EpiGen, Medical Division, Akershus University Hospital, 1478 Lørenskog, Norway.
¹³ Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany; Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹⁴ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹⁵ Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Institut Universitaire de France (IUF), Paris, France.
¹⁶ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany. Electronic address: lucas.massier@helmholtz-munich.de.
¹⁷ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Steno Diabetes Center Copenhagen, 2730 Herlev, Denmark. Electronic address: niklas.mejhert@ki.se.
¹⁸ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Steno Diabetes Center Copenhagen, 2730 Herlev, Denmark. Electronic address: mikael.ryden@ki.se.

PMID: 39983713
DOI: 10.1016/j.cmet.2025.01.012

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

Jiawei Zhong et al. Cell Metab. 2025.

. 2025 Mar 4;37(3):566-569.

doi: 10.1016/j.cmet.2025.01.012. Epub 2025 Feb 20.

Authors

Affiliations

¹ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden.
² Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
³ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁴ Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
⁵ SciLifeLab, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
⁶ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁷ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
⁸ Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Healthy Weight Hub, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
⁹ Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
¹⁰ Medical Department II - Division of Oncology, Gastroenterology, Hepatology and Pneumology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹¹ Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹² Department of Clinical Molecular Biology, EpiGen, Institute of Clinical Medicine, University of Oslo, 1171 Oslo, Norway; EpiGen, Medical Division, Akershus University Hospital, 1478 Lørenskog, Norway.
¹³ Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany; Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹⁴ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; Medical Department III - Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
¹⁵ Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Institut Universitaire de France (IUF), Paris, France.
¹⁶ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany. Electronic address: lucas.massier@helmholtz-munich.de.
¹⁷ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Steno Diabetes Center Copenhagen, 2730 Herlev, Denmark. Electronic address: niklas.mejhert@ki.se.
¹⁸ Department of Medicine (H7), Karolinska Institutet, C2-94, Karolinska University Hospital, 141 86 Stockholm, Sweden; Steno Diabetes Center Copenhagen, 2730 Herlev, Denmark. Electronic address: mikael.ryden@ki.se.

PMID: 39983713
DOI: 10.1016/j.cmet.2025.01.012

Abstract

We developed the Adipose Tissue Knowledge Portal by centralizing previously dispersed datasets, integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men. The platform includes multiple adipose depots, resident cell types, and adipocyte perturbation studies. By providing streamlined data access, the portal enables integrative analyses and serves as a powerful tool to interrogate various dimensions of adipose biology down to the single-cell level.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests in relation to this manuscript.

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adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

Affiliations

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

LinkOut - more resources

Full Text Sources