Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan 20;28(1):55-62.
doi: 10.3779/j.issn.1009-3419.2025.101.02.

[Research Progress of Tumor-associated Neutrophils in the Occurrence and Development of Lung Cancer]

[Article in Chinese]
Xiaoyan Li  1 , Jianjun Zhou  2 , Chaoting Zhao  2 , Yudi Zhang  2   3   4
Affiliations
Review

[Research Progress of Tumor-associated Neutrophils in the Occurrence and Development of Lung Cancer]

[Article in Chinese]
Xiaoyan Li et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Lung cancer is the malignant tumor with the highest mortality rate worldwide. The tumor microenvironment (TME) is a key factor in the progression of lung cancer, composed of tumor cells, signaling molecules, fibroblasts, immune cells, etc. Among them, tumor associated neutrophil (TAN), as an important component of immune cells in the TME, plays multiple roles in tumor cell proliferation, invasion, angiogenesis, and metastasis due to its aberrant function, and is closely associated with poor prognosis. However, there are limited researches on the mechanism of TAN in lung cancer. This review aims to provide more scientific basis for studying the therapeutic targets of lung cancer and developing new drugs by elucidating the different subtypes of TAN and their mechanisms of action in the occurrence and development of lung cancer. .

【中文题目：肿瘤相关中性粒细胞在肺癌发生发展中 的研究进展】 【中文摘要：肺癌在全球范围内是死亡率最高的恶性肿瘤类型。肿瘤微环境（tumor microenvironment, TME）是导致肺癌进展的关键因素，由肿瘤细胞、信号分子、成纤维细胞及免疫细胞等组成。其中，肿瘤相关中性粒细胞（tumor associated neutrophil, TAN）作为构成TME中免疫细胞的重要组成部分，其功能异常在肿瘤细胞的增殖、侵袭、血管生成和转移等环节发挥着多重作用，并与不良预后紧密相关。然而，TAN在肺癌中的作用机制研究较少。本综述通过阐述TAN的不同分型及其在肺癌发生、发展中的作用机制，旨在为研究肺癌的治疗靶点、开发新的药物提供更多的科学依据。 】 【中文关键词：肿瘤相关中性粒细胞；肺肿瘤；肿瘤微环境；免疫】.

Keywords: Immunity; Lung neoplasms; Tumor microenvironment; Tumor-associated neutrophils.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare that there are no conflicts of interest present.

Similar articles

See all similar articles

Cited by

References

    1. Stravopodis DJ, Papavassiliou KA, Papavassiliou AG. . Vistas in non-small cell lung cancer (NSCLC) treatment: of kinome and signaling networks. Int J Biol Sci, 2023, 19(7): 2002-2005. doi: 10.7150/ijbs.83574 - DOI - PMC - PubMed
    1. Bray F, Laversanne M, Sung H, et al. . . Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263. doi: 10.3322/caac.21834 - DOI - PubMed
    1. Qi J, Li M, Wang L, et al. . . National and subnational trends in cancer burden in China, 2005-20: an analysis of national mortality surveillance data. Lancet Public Health, 2023, 8(12): e943-e955. doi: 10.1016/s2468-2667(23)00211-6 - DOI - PubMed
    1. Li Y, Yan B, He S. . Advances and challenges in the treatment of lung cancer. Biomed Pharmacother, 2023, 169: 115891. doi: 10.1016/j.biopha.2023.115891 - DOI - PubMed
    1. Liu Y, Liang J, Zhang Y, et al. . . Drug resistance and tumor immune microenvironment: An overview of current understandings (Review). Int J Oncol, 2024, 65(4): 96. doi: 10.3892/ijo.2024.5684 - DOI - PMC - PubMed