Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions
- PMID: 39992186
- PMCID: PMC11852237
- DOI: 10.1080/14756366.2025.2468853
Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions
Abstract
Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due to its potential role in cancer, ageing, and neuronal degeneration, especially hearing loss. The emerging role of ferroptosis as a crucial mediator in SNHL suggests that it may offer a novel therapeutic target for otoprotection. This review aims to summarise the intricate connection between ferroptosis and SNHL, offering a fresh perspective for exploring targeted therapeutic strategies that could potentially mitigate cochlear cells damage and enhance the quality of life for individuals with hearing impairments.
Keywords: Hearing loss; ferroptosis; otoprotection.
Conflict of interest statement
The authors report no conflicts of interest.
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References
-
- Michels TC, Duffy MT, Rogers DJ.. Hearing loss in adults: differential diagnosis and treatment. Am Fam Physician. 2019;100(2):98–108. - PubMed
-
- Nieman CL, Oh ES.. Hearing loss. Ann Intern Med. 2020;173(11):Itc81–itc96. - PubMed
-
- Ding T, Yan A, Liu K.. What is noise-induced hearing loss? Br J Hosp Med. 2019;80(9):525–529. - PubMed
-
- Tan WJT, Song L.. Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hear Res. 2023;434:108783. - PubMed
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