CXCL12 Derived From ACKR1⁺ Intraplaque Neovessels Mediates CD8⁺ T Cell Recruitment in Human Atherosclerosis

Laura Parma^{1

2}, Nadja Sachs^{2

3}, Nikola Sobczak¹, Zhaolong Li³, Kevin Merchant^{1

2}, Jessica Pauli³, Marie A C Depuydt⁴, Anouk Wezel⁵, Harm J Smeets⁵, Ilze Bot⁴, Bram Slütter⁴, Lars Maegdefessel⁶, Christian Weber^{1

2

7

8}, Johan Duchêne^#^{1

2}, Remco T A Megens^#^{1

2

3

7}

Affiliations

¹ Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University, Munich, Germany (L.P., N.Sobczak, K.M., C.W., J.D., R.T.A.M).
² German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany (L.P., N.Sachs, J.P., L.M., C.W., J.D., R.T.A.M).
³ Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (N. Sachs, Z.L., J.P., L.M.).
⁴ Division of Biotherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Netherlands (M.A.C.D., I.B., B.S.).
⁵ Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, Netherlands (A.W., H.J.S.).
⁶ Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden (L.M.).
⁷ Cardiovascular Research Institute Maastricht, University of Maastricht, Netherlands (C.W., R.T.A.M.).
⁸ Munich Cluster for Systems Neurology, Germany (C.W.).

^# Contributed equally.

PMID: 39993040
DOI: 10.1161/CIRCULATIONAHA.124.072560

CXCL12 Derived From ACKR1⁺ Intraplaque Neovessels Mediates CD8⁺ T Cell Recruitment in Human Atherosclerosis

Laura Parma et al. Circulation. 2025.

. 2025 Feb 25;151(8):581-584.

doi: 10.1161/CIRCULATIONAHA.124.072560. Epub 2025 Feb 24.

Authors

Affiliations

¹ Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University, Munich, Germany (L.P., N.Sobczak, K.M., C.W., J.D., R.T.A.M).
² German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany (L.P., N.Sachs, J.P., L.M., C.W., J.D., R.T.A.M).
³ Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (N. Sachs, Z.L., J.P., L.M.).
⁴ Division of Biotherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Netherlands (M.A.C.D., I.B., B.S.).
⁵ Department of Surgery, Haaglanden Medisch Centrum Westeinde, The Hague, Netherlands (A.W., H.J.S.).
⁶ Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden (L.M.).
⁷ Cardiovascular Research Institute Maastricht, University of Maastricht, Netherlands (C.W., R.T.A.M.).
⁸ Munich Cluster for Systems Neurology, Germany (C.W.).

^# Contributed equally.

PMID: 39993040
DOI: 10.1161/CIRCULATIONAHA.124.072560

No abstract available

Keywords: CD8-positive T-lymphocytes; atherosclerosis; endothelial cells; microscopy; plaque, atherosclerotic; receptors, chemokine; single-cell gene expression analysis.

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CXCL12 Derived From ACKR1⁺ Intraplaque Neovessels Mediates CD8⁺ T Cell Recruitment in Human Atherosclerosis

Affiliations

CXCL12 Derived From ACKR1⁺ Intraplaque Neovessels Mediates CD8⁺ T Cell Recruitment in Human Atherosclerosis

Authors

Affiliations

Conflict of interest statement

Publication types

LinkOut - more resources

Full Text Sources

Research Materials