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Review
. 2025 Feb 10;47(2):113.
doi: 10.3390/cimb47020113.

Folliculogenesis: A Cellular Crosstalk Mechanism

Bianca Viviana Orozco-Galindo  1 , Blanca Sánchez-Ramírez  2 , Cynthia Lizeth González-Trevizo  3 , Beatriz Castro-Valenzuela  1 , Luis Varela-Rodríguez  2 , M Eduviges Burrola-Barraza  2
Affiliations
Review

Folliculogenesis: A Cellular Crosstalk Mechanism

Bianca Viviana Orozco-Galindo et al. Curr Issues Mol Biol. .

Abstract

In vitro embryo production has accelerated in the cattle industry in recent years. Because women are similar to cows, this represents an opportunity to improve women's reproductive protocols. This review focuses on crosstalk communication during folliculogenesis for an in-depth understanding of the events involved in developing the oocyte competence necessary to generate an embryo after fertilization. This knowledge can be used to improve oocytes in in vitro maturation cultures, which would allow us to obtain oocytes of high quality and competence, resulting in successful pregnancies in both women and cows. The first part of this review covers the concepts of cellular crosstalk before puberty in the primordial, primary, and secondary follicles. The next part involves cellular crosstalk after puberty, when gonadotropin hormones act on the ovary, promoting oocyte maturation. The final part comprises a perspective on using cow models to study human ovary physiology.

Keywords: crosstalk; embryo; follicle; folliculogenesis; oocyte.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
World embryo production in cattle over the last fourteen years. IVP: in vitro production. IVD: in vitro embryo-derived. Data were obtained from IETS, https://www.iets.org, (accessed on 20 August 2024).
Figure 2
Figure 2
Cellular crosstalk in a primary follicle. The graphical abstract was created using BioRender. Velarde, A (2025); https//Biorender.com/n26b479 (accessed on 2 January 2025).
Figure 3
Figure 3
Cellular crosstalk in a secondary follicle. The graphical abstract was created using BioRender. Velarde, A (2025); https//Biorender.com/n26b479 (accessed on 2 January 2025).
Figure 4
Figure 4
Cellular crosstalk in an antral follicle. The graphical abstract was created using BioRender. Velarde, A (2025); https//Biorender.com/n26b479 (accessed on 2 January 2025).
See this image and copyright information in PMC

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