Inherent antibacterial properties of mannose-containing polynorbornene glycomaterials

Abstract

Monosaccharides are typically employed as targeting ligands in antimicrobial polymers, yet we discovered that certain glycopolymers prepared by ring-opening metathesis polymerization display inherent antibacterial activity, despite lacking conventional antimicrobial groups. Mannose-functionalized polymers proved potent against Escherichia coli, which could be rescued by adding excess mannose to the growth medium.