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Review
. 2025 Feb;31(1):16-23.
doi: 10.1007/s13365-025-01247-w. Epub 2025 Feb 25.

SARS-CoV-2: A synergy to the Alzheimer's disease

Khaja Moinuddin Shaik #  1 , Deepak Kumar #  1 , Pirangi Srikanth  1 , Sukhendu Nandi  2
Affiliations
Review

SARS-CoV-2: A synergy to the Alzheimer's disease

Khaja Moinuddin Shaik et al. J Neurovirol. 2025 Feb.

Abstract

COVID-19 was a nightmare in humankind's history that challenged our advanced medical technology. All credit goes to the researchers who played a crucial role in curbing COVID-19 and proved our medical technology supremacy. However, COVID-19 has left some mysterious scars on human well-being. It is believed that COVID-19 has a significant negative impact on various cardiovascular (CVS) and central nervous system (CNS) diseases, especially in the case of CNS diseases like Alzheimer's. Surprisingly, COVID-19 affects the respiratory system, whereas Alzheimer's disease (AD) alters brain function. To explain this phenomenon, several hypotheses were proposed, but the mechanism needs to be clearly understood. Another critical thing to be concerned about is that COVID-19 will worsen pre-existing conditions and lead to the onset of AD. In the race to curb COVID-19, the invention of vaccines was speeded up, and it is necessary to fight against COVID-19. However, postvaccination follow-up is mandatory when an individual is a victim of AD. In this review article, we compiled the various dreadful effects of the COVID-19 virus on AD, the Post effects of the virus on AD, and the effect of the COVID-19 vaccination on AD. This article provides a new direction for research concerning COVID-19 and AD.

Keywords: Alzheimer’s disease; COVID 19; Dreadful effect of SARS CoV 2 virus on Alzheimer’s disease; Impact of COVID 19 vaccination on AD; Post COVID 19 effect on AD.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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