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. 2025 Feb 25;15(1):6696.
doi: 10.1038/s41598-025-90391-8.

Combined cerebrospinal fluid sCD163, MMP-9, with serum NCAM1 protein levels for predicting the prognosis of patients with tuberculous meningitis

Tian Yuan  1 , Mingzhu Deng  2 , Yumei Wang  1 , Bo Duan  1 , Qiao Chen  1 , Zhe Fang  1 , Qingxiang Li  1 , Guizhi Zhou  1 , Hongmei Chen  3 , Qi Wang  4
Affiliations

Combined cerebrospinal fluid sCD163, MMP-9, with serum NCAM1 protein levels for predicting the prognosis of patients with tuberculous meningitis

Tian Yuan et al. Sci Rep. .

Abstract

Tuberculous meningitis (TBM) is the most serious type of tuberculosis infection, and there is a lack of accurate diagnostic targets for TBM. Therefore, it is of great clinical and public health significance to find a specific target for early diagnosis and prediction of the prognosis of TBM. From January 2021 to February 2024, 110 TBM patients and 122 patients with non-tumor, non-infectious headaches were admitted to Hunan Chest Hospital. To compare the two groups, cerebrospinal fluid (CSF) levels of sCD163 and MMP-9, as well as serum NCAM1 protein levels, were detected by ELISA. Multivariate logistic regression analysis or Spearman analysis was then performed to investigate the correlation between these protein levels and the MRC (Medical Research Council) stage or the short-term prognosis in TBM patients. sCD163 and MMP-9 were elevated in the CSF of TBM patients compared to controls. Oppositely, the protein levels of serum NCAM1 was decreased. The levels of CSF sCD163, MMP-9 and serum NCAM1 are associated with MRC stage and short-term prognosis of TBM patients, and the combined CSF sCD163, MMP-9 and serum NCAM1 have the best value in predicting the short-term prognosis of TBM patients.

Keywords: MMP-9; NCAM1; Prognosis; Tuberculous meningitis; sCD163.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The expression levels of sCD163 and MMP-9 in 110 TBM patients and 122 non tumor with non infectious headache patients.
Fig. 2
Fig. 2
The expression levels of sCD163 (A), MMP-9 (B) and serum NCAM1 (C) in TBM patients with MRC stage.
Fig. 3
Fig. 3
Correlation analysis between sCD163, NCAM1 and MMP-9 levels and MRC stage in TBM patients.
Fig. 4
Fig. 4
A The ROC curves of sCD163, MMP-9 and NCAM1dan on the short-term prognosis of TBM patients were detected alone or in combination, B: The calibration curves of sCD163, MMP-9 and NCAM1dan for short-term prognosis of TBM patients were detected alone or in combination.
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