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. 2025 Feb 14;17(4):642.
doi: 10.3390/cancers17040642.

Measurement of Melanocytic Choroidal Lesions: Ultrasound Versus Ultrawide-Field Fundus Imaging System

Maria C Baradad-Jurjo  1   2 , Daniel Lorenzo  1 , Estel la Rojas-Pineda  1 , Laura Vigués-Jorba  1 , Rahul Morwani  1 , Lluís Arias  1 , Pere Garcia-Bru  1 , Estefania Cobos  1 , Juan Francisco Santamaria  1 , Carmen Antia Rodríguez-Fernández  1 , Josep M Caminal  1
Affiliations

Measurement of Melanocytic Choroidal Lesions: Ultrasound Versus Ultrawide-Field Fundus Imaging System

Maria C Baradad-Jurjo et al. Cancers (Basel). .

Erratum in

Abstract

Objectives: The aim of this study was to establish the concordance between conventional 20 Mhz ultrasonography and an ultrawide-field (UWF) imaging system (Optos® California) in the measurement of basal diameters of melanocytic choroidal tumors.

Methods: A retrospective study comparing diagnostic tests was conducted in patients with untreated melanocytic choroidal lesions (either nevus or melanoma) who had undergone both UWF imaging and ultrasonography. Only cases with a clear visualization of tumor borders in both imaging modalities were included. Longitudinal and transversal base diameters of the melanocytic tumors were measured by 20 MHz US (one observer) and UWF fundus photography (two observers). Interobserver agreement was assessed for UWF imaging first to validate the technique. Then, UWF imaging measurements were compared with 20 MHz US results.

Results: In total, 106 patient images were reviewed, of which 61 were excluded due to unclear visualization of tumor margins. We found excellent concordance (from ICC and defined Bland-Altman plots) for interobserver and inter-technique agreement in estimating basal diameters when using pseudocolor composite and red laser images by comparing them with 20 MHz US results.

Conclusions: UWF fundus imaging, when complete visualization of the tumor margins is possible, could be as reliable as ultrasonography in the measurement of the basal diameters of choroidal melanocytic tumors.

Keywords: basal diameter; melanocytic choroidal tumors; ultrasonography; ultrawide-field imaging.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Example of measurement of choroidal melanoma transversal diameter (blue line) by ultrasonography (a), ultrawide-field pseudocolor composite (b), red laser imaging (c) and green laser imaging (d). In this case, we found a difficulty in locating the border of the tumor in the images of the green channel with respect to those of the red channel and those taken using the pseudocolor composite.
Figure 2
Figure 2
Bland—Altman plots for inter-observer agreement in tumor size parameters using utra-wide-field imaging. To aid interpretation, the same scale is used in all plots. LoA: limits of agreement.
Figure 3
Figure 3
Bland–Altman plots for the agreement in lesion size parameters between ultrawide-field imaging and 20 MHz ultrasonography. LoA: limits of agreement.
See this image and copyright information in PMC

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