Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb 16;17(4):666.
doi: 10.3390/cancers17040666.

Radiological and Immunohistochemical Characteristics of PitNETs in 79 Patients Undergoing Neurosurgery

Anna Krzentowska  1 , Ryszard Czepko  2 , Dariusz Adamek  3 , Michał Filipowicz  2 , Elżbieta Broniatowska  4 , Filip Gołkowski  1
Affiliations

Radiological and Immunohistochemical Characteristics of PitNETs in 79 Patients Undergoing Neurosurgery

Anna Krzentowska et al. Cancers (Basel). .

Abstract

The human pituitary is a gland located within a small bony box, the sella turcica, under the base of the brain [...].

Keywords: Hardy scale; Knosp scale; invasiveness; pituitary neuroendocrine tumors; transcription factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of invasive and non-invasive tumors in the Hardy scale depending on the transcription factor from which the tumor originated. (Pit-1, pituitary-specific POU-class homeodomain transcription factor; SF 1, steroidogenic factor; TPit, T-box family member TBX19).
Figure 2
Figure 2
Invasiveness on the Knosp scale and Hardy scale of tumors expressing 2 or 3 transcription factors.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Ostrom Q.T., Cioffi G., Gittleman H., Patil N., Waite K., Kruchko C., Barnholtz-Sloan J.S. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016. Neuro Oncol. 2019;21:v1–v100. doi: 10.1093/neuonc/noz150. - DOI - PMC - PubMed
    1. McDowell B.D., Wallace R.B., Carnahan R.M., Chrischilles E.A., Lynch C.F., Schlechte J.A. Demographic differences in incidence for Pituitary adenoma. Pituitary. 2011;14:23–30. doi: 10.1007/s11102-010-0253-4. - DOI - PMC - PubMed
    1. Raverot G., Burman P., McCormack A., Heaney A., Petersenn S., Popovic V., Trouillas J., Dekkers O.M., European Society of Endocrinology European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive Pituitary tumors and carcinomas. Eur. J. Endocrinol. 2018;178:G1–G24. doi: 10.1530/EJE-17-0796. - DOI - PubMed
    1. De Sousa S.M.C., McCormack A.I. Aggressive Pituitary tumors and Pituitary carcinomas. In: Feingold K.R., Anawalt B., Blackman M.R., Boyce A., Chrousos G., Corpas E., de Herder W.W., Dhatariya K., Dungan K., Grossman A., et al., editors. Endotext. MDText.com, Inc.; South Dartmouth, MA, USA: 2000. - PubMed
    1. Lopes M.B.S. The 2017 World Health Organization classification of tumors of the Pituitary gland: A summary. Acta Neuropathol. 2017;134:521–535. doi: 10.1007/s00401-017-1769-8. - DOI - PubMed

LinkOut - more resources