Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Feb 19;17(4):707.
doi: 10.3390/cancers17040707.

Clinical Approaches for the Management of Skin Cancer: A Review of Current Progress in Diagnosis, Treatment, and Prognosis for Patients with Melanoma

Affiliations
Review

Clinical Approaches for the Management of Skin Cancer: A Review of Current Progress in Diagnosis, Treatment, and Prognosis for Patients with Melanoma

Colton Connor et al. Cancers (Basel). .

Abstract

Melanoma represents a significant public health challenge due to its increasing incidence and potential for metastasis. This review will explore the current clinical approaches to the management of melanoma, focusing on advancements in diagnosis, treatment, and prognosis. Methods for early detection and accurate staging have been enhanced by new diagnostic strategies. Treatment modalities have expanded beyond traditional surgical excision to include targeted therapy and immunotherapy. Prognostic assessment has benefited from the development of novel biomarkers and genetic profiling. This review will highlight the progress made in the multidisciplinary management of melanoma, underscoring the importance of continuous research to improve patient outcomes.

Keywords: diagnosis; melanoma; prognosis; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Factors that affect melanoma treatment.
Figure 2
Figure 2
Artificial intelligence in melanoma management.

References

    1. Ernst M., Giubellino A. The Current State of Treatment and Future Directions in Cutaneous Malignant Melanoma. Biomedicines. 2022;10:822. doi: 10.3390/biomedicines10040822. - DOI - PMC - PubMed
    1. Gruber P., Zito P.M. Skin Cancer. StatPearls; Treasure Island, FL, USA: 2025. - PubMed
    1. Linares M.A., Zakaria A., Nizran P. Skin Cancer. Prim. Care. 2015;42:645–659. doi: 10.1016/j.pop.2015.07.006. - DOI - PubMed
    1. Arnold M., Singh D., Laversanne M., Vignat J., Vaccarella S., Meheus F., Cust A.E., de Vries E., Whiteman D.C., Bray F. Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. JAMA Dermatol. 2022;158:495–503. doi: 10.1001/jamadermatol.2022.0160. - DOI - PMC - PubMed
    1. Bell K.J.L., Nijsten T. Melanoma overdiagnosis: Why it matters and what can be done about it. Br. J. Dermatol. 2022;187:459–460. doi: 10.1111/bjd.21750. - DOI - PMC - PubMed

LinkOut - more resources