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. 2025 Feb 14;14(4):1258.
doi: 10.3390/jcm14041258.

Serum Creatinine Level in Relation to Intraluminal Thrombus and Abdominal Aortic Aneurysm Size

Louise Røtzler Holm  1   2 , Jonas Peter Eiberg  1   2   3 , Qasam M Ghulam  1 , Alexander Hakon Zielinski  1 , Rebecca Andrea Conradsen Skov  1   2   3 , On Behalf Of The Coach Research Collaborative
Affiliations

Serum Creatinine Level in Relation to Intraluminal Thrombus and Abdominal Aortic Aneurysm Size

Louise Røtzler Holm et al. J Clin Med. .

Abstract

Objectives: Abdominal aortic aneurysm (AAA) diameter is the primary predictor of AAA rupture. However, smaller aneurysms do rupture, and other parameters are required for a more nuanced risk stratification. Reduced renal function is associated with increased cardiovascular risk and thrombosis, but the impact of renal function on ILT and AAA size remains unknown. This study aimed to investigate the association between creatinine level and volume of ILT and AAA. Methods: In a cross-sectional study, 184 patients with AAA under ultrasound surveillance were included. ILT volume and thickness, and AAA volume and diameter, were measured using three-dimensional contrast-enhanced ultrasound. ILT and AAA measures were compared with creatinine levels. Results: No associations were found between creatinine level and ILT or AAA volume (p = 0.18 and p = 0.41). There were no differences in ILT volume between patients with normal and elevated creatinine levels, when adjusting for AAA size and comorbidities (p = 0.06 and p = 0.54). A positive association was found between ILT volume and AAA volume (p < 0.001). Creatinine level did not influence this association (p = 0.06). Conclusions: In this study, creatinine level did not seem associated with ILT or AAA volume. Longitudinal studies are required to elucidate associations between renal function, clinical outcomes, and ILT and AAA development.

Keywords: abdominal aortic aneurysm; biomarker; creatinine; intraluminal thrombus; ultrasound.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the 184 patients included in the study.
Figure 2
Figure 2
Linear regression analysis of (A): relation between serum creatinine level and ILT volume, and (B): relation between serum creatinine level and AAA volume. No effect of serum creatinine level on ILT volume of −0.10 mL/(μmol/L) was found (p = 0.18), and no effect of serum creatinine level on AAA volume of −0.07 mL/(μmol/L) was found (p = 0.41).
Figure 3
Figure 3
Linear regression analysis of the relation between ILT volume, AAA volume and serum creatinine level. A positive effect of AAA volume on ILT volume of +0.62 mL/mL was found (p < 0.001). The effect of creatinine level was insignificant (p = 0.07).
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