Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Feb 19;14(4):1382.
doi: 10.3390/jcm14041382.

Simultaneous Medullary and Papillary Thyroid Carcinomas: Personal Experience Report and Literature Review

Nadia De Falco  1 , Massimo Agresti  1 , Massimo De Falco  1 , Pasquale Sperlongano  1 , Giancarlo Moccia  1 , Pasquale Luongo  1 , Alessio Cece  1 , Francesco Bove  1 , Francesco Miele  1 , Alfredo Allaria  1 , Francesco Torelli  1 , Paola Bassi  1 , Antonella Sciarra  1 , Stefano Avenia  2 , Paola Della Monica  2 , Federica Colapietra  2 , Marina Di Domenico  2 , Ludovico Docimo  3 , Domenico Parmeggiani  1
Affiliations
Review

Simultaneous Medullary and Papillary Thyroid Carcinomas: Personal Experience Report and Literature Review

Nadia De Falco et al. J Clin Med. .

Abstract

While the frequency of papillary thyroid carcinoma (PTC) has increased in recent decades, both due to improvements in diagnostic procedures and a real, effective percentage increase in cases, the frequency of medullary thyroid carcinoma (MTC), however, has remained almost unchanged, representing 3-5% of thyroid cancer cases. Our experience relates to the observation of cases with the synchronous presence of PTC and MTC, also in chronic autoimmune thyroiditis, and this led us to carry out a brief review of the literature on the subject, with the aim above all of identifying the most correct postoperative therapeutic process.

Keywords: lymphadenectomy; medullary thyroid carcinoma; papillary thyroid carcinoma; total thyroidectomy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Echo images with simultaneous medullary thyroid carcinoma (in the middle) and papillary thyroid carcinoma (the smaller node).
See this image and copyright information in PMC

References

    1. Cabanillas M.E., McFadden D.G., Durante C. Thyroid cancer. Lancet. 2016;388:2783–2795. doi: 10.1016/S0140-6736(16)30172-6. - DOI - PubMed
    1. Biscolla R.P., Ugolini C., Sculli M., Bottici V., Castagna M.G., Romei C., Cosci B., Molinaro E., Faviana P., Basolo F., et al. Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior. Thyroid. 2004;14:946–952. doi: 10.1089/thy.2004.14.946. - DOI - PubMed
    1. Wong R.L., Kazaure H.S., Roman S.A., Sosa J.A. Simultaneous medullary and differentiated thyroid cancer: A population-level analysis of an increasingly common entity. Ann. Surg. Oncol. 2012;19:2635–2642. doi: 10.1245/s10434-012-2357-8. - DOI - PubMed
    1. Kim W.G., Gong G., Kim E., Kim T.Y., Hong S.J., Kim W.B., Shong J.K. Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin. Endocrinol. 2010;72:256–263. doi: 10.1111/j.1365-2265.2009.03622.x. - DOI - PubMed
    1. Machens A., Dralle H. Simultaneous medullary and papillary thyroid cancer: A novel entity? Ann. Surg. Oncol. 2012;19:37–44. doi: 10.1245/s10434-011-1795-z. - DOI - PubMed

LinkOut - more resources