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Clinical Trial
. 1985 May 12;76(19-20):923-6.

[Effect of tiropramide chlorhydrate on intestinal transit time in patients with irritable colon syndrome]

[Article in Italian]
S Passaretti, E Fesce, L Fanti, L Bierti, L Bruno, G Rossini, G Mazzotti, G Ideo, A Tittobello
  • PMID: 4000532
Clinical Trial

[Effect of tiropramide chlorhydrate on intestinal transit time in patients with irritable colon syndrome]

[Article in Italian]
S Passaretti et al. Minerva Med. .

Abstract

The effect of tiropramide hydrochloride--a new spasmolytic drug with calmodulin-independent activity--in correcting alterations of intestinal transit, has been investigated in 40 IBS patients (20 with accelerated and 20 with delayed transit time). Intestinal transit has been evaluated by means of radioopaque markers. Tiropramide hydrochloride, at a dose of 100 mg t.i.d. for 4 weeks, was found significantly more effective than placebo both in normalizing intestinal transit time and in inducing symptomatic relief.

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