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Review
. 2025 Feb 11:12:1492144.
doi: 10.3389/fvets.2025.1492144. eCollection 2025.

Research progress on Haemophilus parasuis vaccines

Yu Duan  1 , Yue Hao  1 , Huapeng Feng  1 , Jianhong Shu  1 , Yulong He  1
Affiliations
Review

Research progress on Haemophilus parasuis vaccines

Yu Duan et al. Front Vet Sci. .

Abstract

Haemophilus parasuis (HPS) is the causative agent of porcine Glässer's disease, which has become prevalent in China in recent years. It is characterized by fibrinous polyserositis, arthritis, and meningitis, but often shows mixed infection with other upper respiratory tract pathogens, causing heavy economic losses to the pig industry. Vaccination is an important means to prevent and control HPS infection, and the currently available vaccines are mainly the inactivated type or subunit vaccines containing immunogenic HPS proteins. This study reviews recent advances in HPS vaccines, analyzes the relative effectiveness of the components of subunit vaccines and discusses the advantages and disadvantages of each vaccine type. The goal is to provide insights for the development of more effective vaccines against Haemophilus parasuis infections in pigs.

Keywords: Glaesserella parasuis; Glässer’s disease; Haemophilus parasuis; pathogenesis; vaccines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
OMP P2 induces IL-8 and CCL4 expression through the NF-κB and MAPK pathways (100), respectively.
See this image and copyright information in PMC

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