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. 2025 Feb 11:15:1517276.
doi: 10.3389/fneur.2024.1517276. eCollection 2024.

Time trends in mechanical thrombectomy (2017-2021): do real-world data reflect advances in evidence?

Christoph Riegler  1   2 , Viktoria Rücker  3 , Regina von Rennenberg  1   2 , Kerstin Bollweg  1   2 , Bastian Cheng  4 , Anna C Alegiani  4 , Fabian Flottmann  5 , Marlena Schnieder  6 , Marielle Ernst  7 , Waltraud Pfeilschifter  8   9   10 , Christoffer Kraemer  8 , Ruben Mühl-Benninghaus  11 , Steffen Tiedt  12   13 , Lars Kellert  13 , Hanna Zimmermann  14 , Felix J Bode  15   16 , Gabor C Petzold  15   16 , Franziska Dorn  17 , Jörg Berrouschot  18 , Albrecht Bormann  19 , Kathleen Bernkopf  20 , Silke Wunderlich  20 , Tobias Boeckh-Behrens  21 , Martina Petersen  22 , Lars Udo Krause  22 , Stephan Lowens  23 , Heinrich J Audebert  1   2 , Eberhard Siebert  24 , Peter U Heuschmann  3   25   26 , Christian H Nolte  1   2   27   28
Affiliations

Time trends in mechanical thrombectomy (2017-2021): do real-world data reflect advances in evidence?

Christoph Riegler et al. Front Neurol. .

Abstract

Background: In recent years, we have witnessed a continuous, evidence-based expansion of indications for endovascular therapy (EVT) in the treatment of ischaemic stroke, driven by advancements in extended time windows and target vessel occlusion. Our study aimed to evaluate the temporal changes in patients' characteristics, treatment, and outcomes in clinical practice.

Methods: We used data from the German Stroke Registry, a large national multicentre prospective registry, which includes all patients receiving EVT for ischaemic stroke at its participating centers. We analysed baseline factors, treatment details, and clinical outcomes [Modified Rankin Scale (mRS) at 3 months] over a 5-year period (2017-2021).

Results: We included 6,251 patients from eight centres. Over time, the characteristics of patients undergoing EVT changed in several aspects (2017 vs. 2021). Patients became older (median age from 76 [IQR: 65-82] to 77 [65-84 years]; ptrend = 0.02), and less severely affected (NIHSS from 15 [11-19] to 13 [8-18]; ptrend <0.001). There was an increase in patients treated more than 6 h after last seen well (22.0% to 28.3%; ptrend<0.001), and more patients were treated for medium vessel occlusion (16.1% to 28.1%; ptrend<0.001). The use of intravenous thrombolysis decreased (52.4% to 40.4%; ptrend<0.01). Good functional outcome declined (percentage of patients with mRS ≤ 2 from 36.0 to 34.9%; aOR 0.94 per year [0.89-0.99]), while mortality at 3 months increased from 25.3% in 2017 to 34.7% in 2021; aOR 1.13 per year [1.07-1.19].

Conclusion: Between 2017 and 2021, there were significant shifts in the demographic and clinical profiles of patients undergoing EVT, along with an expansion in EVT indications. Despite these patients presenting with less severe stroke symptoms, improvements in functional outcomes were not observed, and mortality rates increased. These trends may reflect willingness to treat patients with more severe underlying health conditions.

Keywords: endovascular therapy; ischaemic stroke; mechanical thrombectomy; real world data; time trends.

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Conflict of interest statement

CR received travel grants from ACTICOR Biotech outside the presented study. CHN received compensation for lectures and/or speaker’s bureau from AstraZeneca, BMS, Novartis, Pfizer outside the presented study. FF serves as consultant for Eppdata GmbH outside the presented study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Selection of study centres from the GSR-ET cohort.
Figure 2
Figure 2
Clinical outcome on the Modified Rankin Scale (2017–2021).
See this image and copyright information in PMC

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