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Case Reports
. 2025;11(1):24-0100.
doi: 10.70352/scrj.cr.24-0100. Epub 2025 Feb 8.

A Case of Pleomorphic Adenoma and Ductal Carcinoma In Situ in the Same Mammary Gland

Shiho Nagasawa  1 , Koshi Matsui  1 , Misato Araki  1 , Emi Kanaya  1 , Kohji Takagi  2 , Ryo Muranushi  1 , Yoshihiro Shirai  1 , Toru Watanabe  1 , Takeshi Miwa  1 , Katsuhisa Hirano  1 , Shinichi Sekine  1 , Kazuto Shibuya  1 , Isaya Hashimoto  1 , Isaku Yoshioka  1 , Kenichi Hirabayashi  2 , Tsutomu Fujii  1
Affiliations
Case Reports

A Case of Pleomorphic Adenoma and Ductal Carcinoma In Situ in the Same Mammary Gland

Shiho Nagasawa et al. Surg Case Rep. 2025.

Abstract

Introduction: Pleomorphic adenoma is a benign tumor that frequently occurs in the salivary glands; however, it occurs in the breast rarely. There have been few reports of breast cancer complicated by pleomorphic adenoma of the mammary gland.

Case presentation: A 70-year-old woman was found to have a mass lesion in her left breast during a medical examination. A needle biopsy was performed, and a diagnosis of pleomorphic adenoma was made. We performed a partial mastectomy with a margin of several millimeters from the tumor. Pathological examination revealed a diagnosis of pleomorphic adenoma with ductal carcinoma in situ. The resection margin was sufficient, and the patient was followed up.

Conclusions: Pleomorphic adenoma arising in the mammary gland is difficult to differentiate from adenomyoepithelioma, mucocele-like tumor, and metaplastic carcinoma. Since the tumor can become malignant, resection with a narrow margin is recommended, along with special efforts not to damage the capsule at diagnosis.

Keywords: breast cancer; cartilaginous myxomatous stroma; ductal carcinoma in situ; pleomorphic adenoma.

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Conflict of interest statement

The authors have no related conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. Mammography revealed focal asymmetric density in the left breast.
Fig. 2
Fig. 2. Ultrasound revealed a 6 mm, smooth, well-defined mass in the left C area.
Fig. 3
Fig. 3. (A) Histological imaging. Hematoxylin–eosin stain (×20 at original magnification). This specimen shows a mixture of pleomorphic adenoma and DCIS. (B) Histological imaging. Hematoxylin–eosin stain (×100 at original magnification). In the background of myxochondromatous mesenchymal-like elements, loosely arranged spindle cells and ducts lined by cuboidal cells were observed. (C) Histological imaging. Hematoxylin–eosin stain (×100 at original magnification). Intraductal epithelial proliferation with a solid-to-cribriform pattern. Nuclear atypia was evident, and atypical mitosis was observed.
DCIS, ductal carcinoma in situ
Fig. 4
Fig. 4. (A) Immunohistochemistry Ki-67 antibody in pleomorphic adenoma (×100 at original magnification). (B) Immunohistochemistry Ki-67 antibody in DCIS (×100 at original magnification).
DCIS, ductal carcinoma in situ
See this image and copyright information in PMC

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References

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