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. 1985 Mar 11;13(5):1717-31.
doi: 10.1093/nar/13.5.1717.

A new principle of RNA folding based on pseudoknotting

C W Pleij, K Rietveld, L Bosch
Free PMC article

A new principle of RNA folding based on pseudoknotting

C W Pleij et al. Nucleic Acids Res. .
Free PMC article

Abstract

Tertiary interactions involving hairpin or interior loops of RNA can lead to extended quasi-continuous double helical stem regions, consisting of coaxially stacked segments of duplex RNA, bridged by single-stranded connections. This type of compact folding plays a role in various strategic regions of RNA molecules. Their role in ribosome functioning, RNA splicing and recognition of tRNA-like structures is discussed.

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