Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Feb 27;63(6):1043-1045.
doi: 10.1515/cclm-2025-0211. Print 2025 May 26.

The Friedewald formula strikes back

Affiliations
Free article
Editorial

The Friedewald formula strikes back

Michel R Langlois. Clin Chem Lab Med. .
Free article
No abstract available

PubMed Disclaimer

References

    1. Friedewald, WT, Levy, RI, Fredrickson, DS. Estimation of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502. https://doi.org/10.1093/clinchem/18.6.499 . - DOI
    1. Martin, SS, Blaha, MJ, Elshazly, MB, Toth, PP, Kwiterovich, PO, Blumenthal, RS, et al.. Comparison of a novel method vs the Friedewald equation for estimating low density lipoprotein cholesterol levels from the standard lipid profile. JAMA 2013;310:2061–8. https://doi.org/10.1001/jama.2013.280532 . - DOI
    1. Grundy, SM, Stone, NJ, Bailey, AL, Beam, C, Birtcher, KK, Blumenthal, RS, et al.. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart association task force on clinical practice guidelines. J Am Coll Cardiol 2019;73:e285–e350, https://doi.org/10.1016/j.jacc.2018.11.003 . - DOI
    1. Langlois, MR, Nordestgaard, BG, Langsted, A, Chapman, MJ, Aakre, KM, Baum, H, et al.. European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative. Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM. Clin Chem Lab Med 2020;58:496–517. https://doi.org/10.1515/cclm-2019-1253 . - DOI
    1. Sampson, M, Ling, C, Sun, Q, Harb, R, Ashmaig, M, Warnick, R, et al.. A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia. JAMA Cardiol 2020;5:540–8. https://doi.org/10.1001/jamacardio.2020.0013 . - DOI

Publication types

LinkOut - more resources