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. 2025 Feb 25:17:17562872251322658.
doi: 10.1177/17562872251322658. eCollection 2025 Jan-Dec.

Physical activity and testicular cancer survivorship health-related quality of life: a scoping review

Michael J Rovito  1 , Keith Brazendale  2 , Samantha Gibson  2 , Sydney Martinez  2 , Ciaran Fairman  3 , Craig Badolato  4 , Timothy Lyon  5 , Bryce Baird  5 , Jaclyn Langan  2 , M K Leslie  2
Affiliations

Physical activity and testicular cancer survivorship health-related quality of life: a scoping review

Michael J Rovito et al. Ther Adv Urol. .

Abstract

Background: While the benefits of physical activity (PA) for cancer survivors are well-documented, there is limited research specifically exploring its effects on health-related quality of life (HRQoL) among testicular cancer (TC) survivors. This review aims to examine the available literature on the relationship between PA and HRQoL in TC survivors post-treatment.

Objective: To identify and synthesize existing studies on the effects of PA on HRQoL outcomes in TC survivors.

Eligibility criteria: Studies that examined the relationship between PA, TC survivorship, and HRQoL across various phases of survivorship were included. Only peer-reviewed articles and gray literature addressing these topics were considered.

Sources of evidence: A systematic search was conducted across seven databases and gray literature. Articles were evaluated based on titles, abstracts, and full-text reviews for inclusion.

Charting methods: Following Arksey and O'Malley's scoping review framework and PRISMA-ScR guidelines, studies were charted for key findings regarding the effects of PA on cancer-related fatigue, psychosocial outcomes, and HRQoL in TC survivors. The search also focused on identifying barriers to PA adherence and gaps in the current literature.

Results: Three studies were examined: one experimental study, one feasibility study, and one cross-sectional study. Findings suggested that PA interventions could reduce cancer-related fatigue, improve psychosocial well-being, and enhance HRQoL indicators such as vitality, self-esteem, and social functioning. High-intensity interval training showed short-term benefits, while low-intensity activities demonstrated feasibility for broader adoption. Adherence barriers included treatment side effects and psychosocial factors. Limitations included small sample sizes, self-reported data, and lack of long-term follow-up.

Conclusion: The findings suggest that PA can improve HRQoL in TC survivors, but significant gaps remain, particularly in terms of longitudinal studies, diverse populations, and tailored interventions. Future research should focus on developing scalable, sustainable PA interventions that address adherence and long-term health outcomes for TC survivors.

Keywords: health-related quality of life; physical activity; review; testicular cancer.

Plain language summary

A review of evidence between physical activity and testicular cancer A scoping review was conducted to understand the breadth and depth of available literature on the relationship between testicular cancer survivorship and if physical activity can have a net-positive benefit to patient-reported post-treatment outcomes. Overall, the studies indicated a positive net effect of physical activity and testicular cancer survivorship patient-reported outcomes, particularly around the increased perceived need for exercise, reduced cancer-related fatigue, and a lessening of anxiety and depressive symptoms.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
PRISMA flowchart.
See this image and copyright information in PMC

References

    1. Mercieca-Bebber R, Naherfun SK, Rincones O, et al.. Patient reported outcomes associated with treatments for testicular cancer: a systematic review. Patient Relat Outcome Meas 2021; 12: 129. - PMC - PubMed
    1. American Cancer Society. Risk factors for testicular cancer, https://www.cancer.org/cancer/testicular-cancer/causes-risks-prevention/... (2021, accessed 14 October 2021).
    1. Miller KD, Nogueira L, Mariotto AB, et al.. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin 2019; 69(5): 363–385. - PubMed
    1. Lerro CC, Robbins AS, Fedewa SA, et al.. Disparities in stage at diagnosis among adults with testicular germ cell tumors in the National Cancer Data Base. Urol Oncol 2014; 32(1): 23.e15–21. - PubMed
    1. Surveillance, Epidemiology, and End Results Program (SEER). Cancer stat facts: testicular cancer, https://seer.cancer.gov/statfacts/html/testis.html#ref05%20SEER%202015 (2021, accessed 19 October 2021).

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