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Review
. 2025 Feb 12:13:1527854.
doi: 10.3389/fbioe.2025.1527854. eCollection 2025.

Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation

Nathalia Silva Dutra Alves  1 , Gustavo Roncoli Reigado  1 , Mayara Santos  1 , Izabela Daniel Sardinha Caldeira  1 , Henrique Dos Santos Hernandes  2 , Bruna Leticia Freitas-Marchi  3 , Elina Zhivov  4 , Felipe Santiago Chambergo  2 , Viviane Abreu Nunes  1
Affiliations
Review

Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation

Nathalia Silva Dutra Alves et al. Front Bioeng Biotechnol. .

Abstract

Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.

Keywords: bioengineered skin substitutes; burns; chronic wounds; regenerative medicine; rejuvenation; skin regeneration; stem cells; wound healing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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