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. 2025 Jul 1;110(7):1623-1627.
doi: 10.3324/haematol.2024.286311. Epub 2025 Feb 27.

Prognostic relevance of variant allele frequency for treatment outcomes in patients with acute myeloid leukemia: a study by the Spanish PETHEMA registry

Rafael Colmenares  1 , Noemi Alvarez  1 , Eva Barragan  2 , Blanca Boluda  3 , Maria J Larrayoz  4 , Maria Carmen Chillon  5 , Elena Soria-Saldise  6 , Cristina Bilbao  7 , Joaquin Sanchez-Garcia  8 , Teresa Bernal  9 , David Martinez-Cuadron  3 , Cristina Gil  10 , Josefina Serrano  8 , Carlos Rodriguez-Medina  7 , Juan Bergua  11 , Jose A Perez-Simon  6 , Maria Calbacho  1 , Juan M Alonso-Dominguez  12 , Jorge Labrador  13 , Mar Tormo  14 , Pilar Herrera-Puente  15 , Cristina Martin-Arriscado  16 , Andres Arroyo-Barea  1 , Inmaculada Rapado  1 , Claudia Sargas  2 , Iria Vazquez  4 , Maria J Calasanz  4 , Teresa Gomez-Casares  7 , Ramon Garcia-Sanz  5 , Rebeca Rodriguez-Veiga  3 , Joaquin Martinez-Lopez  1 , Rosa Ayala  17 , Pau Montesinos  18 , Pethema Group  19
Affiliations

Prognostic relevance of variant allele frequency for treatment outcomes in patients with acute myeloid leukemia: a study by the Spanish PETHEMA registry

Rafael Colmenares et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Study design and Kaplan-Meier curve of overall survival depending on the cutoff of variant allele frequencies of some genes. (A) Study design. (B) Kaplan-Meier curve of overall survival, depending on the cutoff of the variant allele frequencies (VAF) of ASXL1, JAK2, RUNX1, SRSF2, TET2 and TP53. The entire diagnostic cohort is represented. Blue represents patients with VAF below the cutoff and red represents patients with VAF above the cutoff. CR: complete remission; Allo-HSCT: allogeneic hematopoietic stem-cell transplantation; Auto-HCST: autologous hematopoietic stem-cell transplantation; ELN: European LeukemiaNet; LDAC: low-dose cytarabine; OS: overall survival.
See this image and copyright information in PMC

References

    1. Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140(12):1345-1377. - PubMed
    1. Sargas C, Ayala R, Larráyoz MJ, et al. Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a reallife cohort of the PETHEMA group. Blood Cancer J. 2023;13(1):77. - PMC - PubMed
    1. Sargas C, Ayala R, Larráyoz MJ, et al. Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real life data from the PETHEMA registry. Cancers (Basel). 2023;15(2):438. - PMC - PubMed
    1. Goel S, Hall J, Pradhan K, et al. High prevalence and allele burden-independent prognostic importance of p53 mutations in an inner-city MDS/AML cohort. Leukemia. 2016;30(8):1793-1795. - PubMed
    1. Hamilton BK, Rybicki L, Hirsch C, et al. Mutation clonal burden and allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia and myelodysplastic syndromes. Bone Marrow Transplant. 2019;54(8):1281-1286. - PubMed

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