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Review
. 2025 Jun;298(3):247-253.
doi: 10.1111/jmi.13400. Epub 2025 Feb 27.

De-risking transformative microscopy technologies for broad adoption

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Review

De-risking transformative microscopy technologies for broad adoption

Jesse Aaron et al. J Microsc. 2025 Jun.

Abstract

The past 20 years have seen a paradigm-shifting explosion of new optical microscopy technologies aimed at uncovering fundamental biological insights. Yet only a small portion 'cross the finish line' into wide adoption by the life science community. We contend that this is not primarily due to a lack of technical prowess or utility. Rather, many risks can conspire to derail the adoption of potentially disruptive technologies. One way to address these challenges is to de-risk paradigm-shifting inventions within open-access technology incubators. Here we detail the framework needed to shepherd innovative microscopy techniques through the often-treacherous adoption landscape to enable transformative scientific output.

Keywords: microscopy development; microscopy dissemination; technology de-risking; technology validation.

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References

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