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Review
. 2025 Apr;57(4):390-418.
doi: 10.1055/a-2524-2596. Epub 2025 Feb 27.

Endoscopic ultrasound-guided tissue sampling: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review

Antonio Facciorusso #  1 , Marianna Arvanitakis #  2 , Stefano Francesco Crinò  3 , Carlo Fabbri  4 , Adele Fornelli  5 , John Leeds  6 , Livia Archibugi  7 , Silvia Carrara  8   9 , Jahnvi Dhar  10 , Paraskevas Gkolfakis  11 , Beate Haugk  12 , Julio Iglesias Garcia  13 , Bertrand Napoleon  14 , Ioannis S Papanikolaou  15 , Andrada Seicean  16 , Pauline M C Stassen  17 , Peter Vilmann  18   19 , Tony C Tham  20 , Lorenzo Fuccio  21
Affiliations
Free article
Review

Endoscopic ultrasound-guided tissue sampling: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review

Antonio Facciorusso et al. Endoscopy. 2025 Apr.
Free article

Abstract

This Technical and Technology Review from the European Society of Gastrointestinal Endoscopy (ESGE) represents an update of the previous document on the technical aspects of endoscopic ultrasound (EUS)-guided sampling in gastroenterology, including the available types of needle, technical aspects of tissue sampling, new devices, and specimen handling and processing. Among the most important new recommendations are:ESGE recommends end-cutting fine-needle biopsy (FNB) needles over reverse-bevel FNB or fine-needle aspiration (FNA) needles for tissue sampling of solid pancreatic lesions; FNA may still have a role when rapid on-site evaluation (ROSE) is available.ESGE recommends EUS-FNB or mucosal incision-assisted biopsy (MIAB) equally for tissue sampling of subepithelial lesions ≥20 mm in size. MIAB could represent the first choice for smaller lesions (<20 mm) if proper expertise is available.ESGE does not recommend the use of antibiotic prophylaxis before EUS-guided tissue sampling of solid masses and EUS-FNA of pancreatic cystic lesions.

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Conflict of interest statement

L. Archibugi has received consultancy fees from Boston Scientific (2024). M. Arvanitakis has provided consultancy and received support for courses from Pentax and Boston Scientific (both 2024 to present). S. Carrara has received consultancy fees from Olympus and Boston Scientific (both 2022 to 2024). C. Fabbri has provided consultancy to Boston Scientific (2020 to present) and Steris (2024). J. Iglesias-Garcia has received speaker’s and advisor fees from Fujifilm (2022 to present), Boston Scientific (2016 to present), and Medi-Globe (2021 to present). J. Leeds has received speaker’s and advisor fees from Medtronic, Boston Scientific, Olympus, and Viatris (2015 to present); course support from Boston Scientific, Medtronic, Olympus, and Cook Medical (2018 to present); he is Secretary of the Pancreatic Society of Great Britain and Ireland (2022 to present). B. Napoleon has received fees for teaching from Olympus, Boston Scientific, and MaunaKea (all 2018 to present). P. Vilmann has provided consultancy to Medi-Globe (1992 to present). S.F. Crinò, J. Dhar, A. Facciorusso, A. Fornelli, L. Fuccio, P. Gkolfakis, B. Haugk, I.S. Papanikolaou, A. Seicean, P.M.C. Stassen, and T.C. Tham declare that they have no conflict of interest.

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