Distinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders

Shitong Xiang¹, Chao Xie¹, Xiao Xiao², Tobias Banaschewski³, Gareth J Barker⁴, Arun L W Bokde⁵, Herta Flor⁶, Antoine Grigis⁷, Hugh Garavan⁸, Penny Gowland⁹, Andreas Heinz¹⁰, Rüdiger Brühl¹¹, Jean-Luc Martinot¹², Marie-Laure Paillère Martinot¹³, Jani Penttilä¹⁴, Eric Artiges¹⁵, Frauke Nees¹⁶, Dimitri Papadopoulos Orfanos⁷, Luise Poustka¹⁷, Sarah Hohmann³, Nathalie Holz³, Christian Baeuchl¹⁸, Michael N Smolka¹⁸, Nilakshi Vaidya¹⁹, Henrik Walter¹⁰, Robert Whelan²⁰, Marina Bobou²¹, John Broulidakis²², Betteke Maria van Noort²³, Argyris Stringaris²⁴, Zuo Zhang²⁵, Lauren Robinson²⁶, Jeanne Winterer²⁷, Yuning Zhang²⁸, Sinead King²⁹, Ulrike Schmidt³⁰, Julia Sinclair³¹, Sylvane Desrivières²⁵, Gunter Schumann³², Benjamin Becker³³, Trevor W Robbins³⁴, Tianye Jia³⁵, Jianfeng Feng³⁶; IMAGEN Consortium and Stratify Consortium

Affiliations

¹ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Behavioral and Cognitive Neuroscience Center, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
³ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany.
⁴ Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, WC2R 2LS, UK.
⁵ Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin D02 PN40, Ireland.
⁶ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, 68131, Germany.
⁷ NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91191, France.
⁸ Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA.
⁹ Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
¹⁰ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 10117, Germany.
¹¹ Physikalisch-Technische Bundesanstalt (PTB), Berlin, 10587, Germany.
¹² Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France.
¹³ Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France; AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, 75013, France.
¹⁴ Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, 15101, Finland.
¹⁵ Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France; Department of Psychiatry, Lab-D Psy, EPS Barthélémy Durand, Etampes, 91150, France.
¹⁶ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin D02 PN40, Ireland; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, 24105, Germany.
¹⁷ Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, 69115, Germany.
¹⁸ Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, 01062, Germany.
¹⁹ Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, 10117, Germany.
²⁰ School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, D02 PN40, Ireland.
²¹ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, WC1E 6BT, UK.
²² Department of Experimental Psychology, University of Oxford, Oxford, OX2 6GG, UK.
²³ Department of Psychology, MSB Medical School Berlin, Berlin, 14197, Germany.
²⁴ Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, WC1E 6BT, UK.
²⁵ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
²⁶ Institute of Clinical Psychology Training and Research, Oxford University, Oxford, OX2 6GG, UK; Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; South London and Maudsley NHS Foundation Trust, London, BR3 3BX, UK.
²⁷ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 10117, Germany; Department of Education and Psychology, Freie Universität Berlin, Berlin, 14195, Germany.
²⁸ Psychology Department, University of Southampton, Southampton, SO17 1PS, UK.
²⁹ Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, 01062, Germany; School of Medicine, Center for Neuroimaging, Cognition and Genomics, National University of Ireland (NUI) Galway, Galway, H91 TK33, Ireland.
³⁰ Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; South London and Maudsley NHS Foundation Trust, London, BR3 3BX, UK.
³¹ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.
³² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, 10117, Germany; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai 200433, China.
³³ State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China; Department of Psychology, The University of Hong Kong, Hong Kong 999077, China.
³⁴ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge; Cambridge, CB2 3EB, UK. Electronic address: twr2@cam.ac.uk.
³⁵ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai 200433, China; Institute of Psychiatry, Psychology & Neuroscience, King's College, London, WC2R 2LS, UK. Electronic address: tianyejia@fudan.edu.cn.
³⁶ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China; Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Hangzhou 321004, China. Electronic address: jffeng@fudan.edu.cn.

PMID: 40016035
DOI: 10.1016/j.scib.2025.02.026

Distinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders

Shitong Xiang et al. Sci Bull (Beijing). 2025.

. 2025 Jul 15;70(13):2061-2065.

doi: 10.1016/j.scib.2025.02.026. Epub 2025 Feb 18.

Authors

Affiliations

¹ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Behavioral and Cognitive Neuroscience Center, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
³ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany.
⁴ Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, WC2R 2LS, UK.
⁵ Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin D02 PN40, Ireland.
⁶ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, 68131, Germany.
⁷ NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, 91191, France.
⁸ Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA.
⁹ Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
¹⁰ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 10117, Germany.
¹¹ Physikalisch-Technische Bundesanstalt (PTB), Berlin, 10587, Germany.
¹² Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France.
¹³ Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France; AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, 75013, France.
¹⁴ Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, 15101, Finland.
¹⁵ Université Paris-Saclay, Université Paris Cité, INSERM U1299 "Trajectoires Développementales & Psychiatrie", Ecole Normale Supérieure Paris-Saclay, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, 91191, France; Department of Psychiatry, Lab-D Psy, EPS Barthélémy Durand, Etampes, 91150, France.
¹⁶ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin D02 PN40, Ireland; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, 24105, Germany.
¹⁷ Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, 69115, Germany.
¹⁸ Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, 01062, Germany.
¹⁹ Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, 10117, Germany.
²⁰ School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, D02 PN40, Ireland.
²¹ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, WC1E 6BT, UK.
²² Department of Experimental Psychology, University of Oxford, Oxford, OX2 6GG, UK.
²³ Department of Psychology, MSB Medical School Berlin, Berlin, 14197, Germany.
²⁴ Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, WC1E 6BT, UK.
²⁵ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
²⁶ Institute of Clinical Psychology Training and Research, Oxford University, Oxford, OX2 6GG, UK; Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; South London and Maudsley NHS Foundation Trust, London, BR3 3BX, UK.
²⁷ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 10117, Germany; Department of Education and Psychology, Freie Universität Berlin, Berlin, 14195, Germany.
²⁸ Psychology Department, University of Southampton, Southampton, SO17 1PS, UK.
²⁹ Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, 01062, Germany; School of Medicine, Center for Neuroimaging, Cognition and Genomics, National University of Ireland (NUI) Galway, Galway, H91 TK33, Ireland.
³⁰ Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK; South London and Maudsley NHS Foundation Trust, London, BR3 3BX, UK.
³¹ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK.
³² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, 10117, Germany; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai 200433, China.
³³ State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China; Department of Psychology, The University of Hong Kong, Hong Kong 999077, China.
³⁴ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge; Cambridge, CB2 3EB, UK. Electronic address: twr2@cam.ac.uk.
³⁵ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Centre for Population Neuroscience and Stratified Medicine (PONS Centre), ISTBI, Fudan University, Shanghai 200433, China; Institute of Psychiatry, Psychology & Neuroscience, King's College, London, WC2R 2LS, UK. Electronic address: tianyejia@fudan.edu.cn.
³⁶ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China; Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Hangzhou 321004, China. Electronic address: jffeng@fudan.edu.cn.

PMID: 40016035
DOI: 10.1016/j.scib.2025.02.026

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Distinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders

Affiliations

Distinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders

Authors

Affiliations

LinkOut - more resources

Full Text Sources