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. 2025 Mar;46(3):183-185.
doi: 10.1016/j.it.2025.02.004. Epub 2025 Feb 26.

Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death

Bhesh Raj Sharma  1 , Thirumala-Devi Kanneganti  2
Affiliations

Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death

Bhesh Raj Sharma et al. Trends Immunol. 2025 Mar.

Abstract

Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

References

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    1. Wright SS et al. (2025) Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. Cell 188 (2), 280–291 e17. - PubMed

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