Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 Feb 27;15(1):7001.
doi: 10.1038/s41598-025-90283-x.

Syntonic phototherapy versus part time occlusion for treatment of refractive amblyopia

Sanaa Ahmed Mohamed  1 , Adel Mohammed Abdel-Wahab Khalil  2 , Maha Emhammed Almokhtar Aljaghmani  2
Affiliations
Randomized Controlled Trial

Syntonic phototherapy versus part time occlusion for treatment of refractive amblyopia

Sanaa Ahmed Mohamed et al. Sci Rep. .

Abstract

To evaluate the effectiveness of syntonic phototherapy and compare it with partial time occlusion to improve visual acuity in cases of refractive amblyopia. This study is a prospective, comparative, and randomized study. It included 40 patients. Their mean age ± SD was 14.45 ± 10.03 years (Range: 6-45 years). Twenty patients were subjected to partial time occlusion of the sound eye, and 20 received syntonic phototherapy treatment.The study revealed that there was statistically significant improvement in visual functions, UCVA, BCVA, AOP, and functional visual field in patients who were subjected to syntonic phototherapy, whereas the improvement of UCVA and BCVA in patients who were subjected to conventional treatment was satisfactory but less than that reported by syntonic therapy. Visual acuity increased significantly in patients with amblyopia after syntonic phototherapy as compared to partial occlusion therapy.

Keywords: Amblyopia; Anisometropia; Part-time occlusion; Syntonic phototherapy.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A patient under syntonic treatment.
Fig. 2
Fig. 2
Visual field being plotted by kinetic campimeter.
Fig. 3
Fig. 3
(A) shows the pre-syntonic visual field, (B) shows the visual field after 8 sessions, (C) shows the visual field after 16 sessions, (D) shows the visual field after 24 sessions.
See this image and copyright information in PMC

References

    1. Talebnejad, M. R. et al. The prevalence and causes of low vision and visual impairment in school-aged children: the Shiraz Pediatric Eye Study. J. Curr. Ophthalmol.34, 333–340 (2022). - PMC - PubMed
    1. Yazdani, N. et al. Part-time versus full-time occlusion therapy for treatment of amblyopia: a meta-analysis. J. Curr. Ophthalmol.29, 76–84 (2017). - PMC - PubMed
    1. Webber, A. L. The functional impact of amblyopia. Clin. Experimental Optometry. 101, 443–450 (2018). - PubMed
    1. Barrett, B. T., Bradley, A. & Candy, T. R. The relationship between anisometropia and amblyopia. Prog. Retin. Eye Res.36, 120–158 (2013). - PMC - PubMed
    1. Shetty, N. K. & Prathyusha, I. Factors influencing occlusion therapy in refractive amblyopia. J. Med. Res.5, 15–21 (2019).

Publication types

LinkOut - more resources