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Case Reports
. 2025 Feb 26;12(3):e01638.
doi: 10.14309/crj.0000000000001638. eCollection 2025 Mar.

Extensive Esophageal Papillomatosis: A Rare Disease With Difficult Diagnosis

Miriam Chinzon  1 , Sergio Barbosa Marques  1 , Eduardo Guimarães Hourneaux de Moura  1
Affiliations
Case Reports

Extensive Esophageal Papillomatosis: A Rare Disease With Difficult Diagnosis

Miriam Chinzon et al. ACG Case Rep J. .

Abstract

Extensive esophageal papillomatosis is a rare condition with uncertain pathophysiology. We present a case involving a 78-year-old woman, with no notable habits or addictions, who presented with dysphagia and weight loss. She was diagnosed with extensive esophageal papillomatosis, causing esophageal substenosis. Diagnosis of dysplasia in such cases are challenging, and management of the risk of malignant transformation remains uncertain.

Keywords: dysplasia; endoscopy; esophageal; papillomatosis.

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Figures

Figure 1.
Figure 1.
100×: Chronic esophagitis without dysplasia. Immunohistochemical tests returned negative results for fungi.
Figure 2.
Figure 2.
100×: Granular and villous irregular surface area. Virtual chromoendoscopy revealed dilated capillaries with a spiral morphology in the irregular area.
Figure 3.
Figure 3.
100×: Chronic esophagitis with basal layer hyperplasia, lymphocyte exocytosis, focal activity, mild papillomatosis, and parakeratosis. Immunohistochemistry: P16: Positive (focal)/Ki67: Positive (basal third)/P53: Positive (nonmutated pattern).
Figure 4.
Figure 4.
Ulcerated lesion on the gingival mucosa.
See this image and copyright information in PMC

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