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. 2025 Mar 12;147(10):8118-8124.
doi: 10.1021/jacs.5c00330. Epub 2025 Feb 28.

Catalyst-Controlled Regiodivergent Oxidation of Unsymmetrical Diols

Samson B Zacate  1 , Jonas Rein  1 , Soren D Rozema  2 , Reginald A Annor  1 , Scott J Miller  2 , Song Lin  1
Affiliations

Catalyst-Controlled Regiodivergent Oxidation of Unsymmetrical Diols

Samson B Zacate et al. J Am Chem Soc. .

Abstract

In this work we use aminoxyl-peptide conjugates to catalyze the regiodivergent oxidation of unsymmetrical diols. Through structural tuning of both the aminoxyl catalytic core and the chiral peptide backbone, we achieved catalyst control that either reinforces or overrides the intrinsic steric bias, leading to oxidation of either the less hindered or the more hindered alcohol in high selectivity.

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Conflict of interest statement

The authors declare no competing financial interest.

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