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Review
. 2025 Apr;57(3):481-484.
doi: 10.1016/j.transproceed.2025.02.021. Epub 2025 Feb 28.

Case Report: A Unique Case of Hemophagocytic Lymphohistiocytosis in Heart Transplant

Boaz Elad  1 , Wojciech Rzechorzek  2 , Kelly Axsom  2 , Justin Fried  2 , Farhana Latif  2 , Adil Yunis  2 , Carolyn Hennecken  2 , Rubin Salazar  2 , Kyung T Oh  2 , David L Diuguid  3 , Andrew H Lipsky  3 , Ron S Gejman  3 , Gabriel Sayer  2 , Nir Uriel  2 , Dor Lotan  2
Affiliations
Review

Case Report: A Unique Case of Hemophagocytic Lymphohistiocytosis in Heart Transplant

Boaz Elad et al. Transplant Proc. 2025 Apr.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare and deadly disease that presents significant diagnostic challenges. The complexity of diagnosis and treatment is further increased among transplant recipients, yet reports on solid organ transplants, and specifically heart transplant recipients, remain scarce. Herein, we elucidate the diagnostic journey, clinical evolution, and therapeutic approach undertaken for a heart transplant recipient afflicted with hemophagocytic lymphohistiocytosis, followed by a review of the literature.

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Conflict of interest statement

Declaration of competing interest All the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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