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. 2025 Mar:277:74-85.
doi: 10.1016/j.schres.2025.02.004. Epub 2025 Feb 28.

Building a two-state learning healthcare system for persons with first episode psychosis

Jill A Marsteller  1 , Richard W Goldberg  2 , Yasmine Boumaiz  2 , Megan B E Jumper  3 , Jessica Taylor  2 , Arunadevi Saravana  2 , Robert W Buchanan  4 , K N Roy Chengappa  5 , Catherine G Conroy  3 , Faith Dickerson  6 , Arielle Ered  3 , Nev Jones  7 , Christian G Kohler  3 , Julie Kreyenbuhl  2 , Alicia Lucksted  2 , Russell L Margolis  8 , Deborah Medoff  2 , Peter Phalen  2 , Deepak K Sarpal  5 , William R Smith  5 , Crystal Vatza  3 , Monica E Calkins  3 , Melanie E Bennett  2
Affiliations

Building a two-state learning healthcare system for persons with first episode psychosis

Jill A Marsteller et al. Schizophr Res. 2025 Mar.

Abstract

The Connection Learning Healthcare System (CLHS) represents a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland working together to provide the best evidence-based care for persons with first episode psychosis. Developing an integrated, two-state system required unification and harmonization of data collection, training, consultation, research, and dissemination activities. Here we describe the model that supported these efforts and our experience creating an active two-state learning healthcare system. We also review areas of ongoing attention and offer lessons learned.

Keywords: First episode psychosis; Learning healthcare system.

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Conflict of interest statement

Declaration of competing interest Robert W. Buchanan has consulted for Boehringer-Ingelheim; serves on the Data Safety and Monitoring Boards of Roche, Merck and Newron; and has served on the Advisory Boards of Merck, Acadia, Karuna, and Neurocrine. All other authors have no declarations.

References

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