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Review
. 2025 Apr;1872(4):119927.
doi: 10.1016/j.bbamcr.2025.119927. Epub 2025 Feb 27.

Lactylation and regulated cell death

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Review

Lactylation and regulated cell death

Wenlong Zhang et al. Biochim Biophys Acta Mol Cell Res. 2025 Apr.

Abstract

Lactylation, a newly identified post-translational modification, entails the attachment of lactate to lysine residues within proteins, profoundly modulating diverse cellular mechanisms underlying regulated cell death (RCD). This modification encompasses two primary categories: histone lactylation and non-histone lactylation. Histone lactylation assumes a pivotal regulatory function in the RCD process, primarily by modulating the transcriptional landscape of genes implicated in cell death. In contrast, non-histone lactylation exerts its influence by targeting transferases, transcription, cell cycle progression, death pathways, and metabolic processes that are intricately involved in RCD. This review provides a comprehensive overview of recent breakthroughs in understanding how lactylation regulates RCD, while also offering insights into potential avenues for future research, thereby deepening our comprehension of cellular fate determination.

Keywords: Apoptosis; Autophagy; Ferroptosis; Lactylation; Pyroptosis.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

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