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Case Reports
. 2025 Mar;31(3):579-582.
doi: 10.3201/eid3103.240946.

Haemophilus influenzae Type b Meningitis in Infants, New York, New York, USA, 2022-2023

Anne Ewing, Sydney Haldeman, Megan J Job, Caitlin Otto, Adam J Ratner
Case Reports

Haemophilus influenzae Type b Meningitis in Infants, New York, New York, USA, 2022-2023

Anne Ewing et al. Emerg Infect Dis. 2025 Mar.

Abstract

Two unvaccinated infants residing in the same borough of New York, New York, USA, had Haemophilus influenzae type b meningitis develop 1 year apart. Whole-genome sequencing and phylogenetic analysis revealed the isolates shared a previously undescribed multilocus sequence type and were more closely related to each other than to other sequenced strains.

Keywords: Haemophilus influenzae type b; New York; bacteria; epidemiology; infants; meningitis/encephalitis; whole-genome sequencing.

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Figures

Figure
Figure
Genetic distance tree constructed to assess genetic relatedness among strains in study of Haemophilus influenzae type b (Hib) meningitis in infants, New York, New York, USA, 2022–2023. We constructed the tree using Mashtree (10) for Hib strains from the 2 New York patients (red asterisk) and reference sequences from GenBank (Appendix Table). Rings are color-coded to indicate MLST (inner ring) and CC (outer ring). Tree was rooted using the genome for NCTC 8468 (GenBank accession nos. GCA_90147285.1), a division II, sodC-containing Hib strain distantly related to other sequenced Hib isolates. Branch lengths represent mash distances. CC, clonal complex; MLST, multilocus sequence type; NA, not available.
See this image and copyright information in PMC

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