. 2025 Apr 19:53:126929.

doi: 10.1016/j.vaccine.2025.126929. Epub 2025 Mar 1.

Workshop report: One Health challenges and knowledge gaps in the control of intracellular infections with a focus on tuberculosis and leishmaniasis

Michele Miller¹, Maria Adelaida Gómez², Rachel Tanner³, Samantha Vermaak⁴, Bernardo Villarreal-Ramos⁵; VALIDATE Network One Health Working Group

Collaborators, Affiliations

Collaborators

VALIDATE Network One Health Working Group:
Salem Almujri⁶, Federico Blanco⁷, Thouraya Boussoffara⁸, Richard Burchmore⁹, Peter Buss¹⁰, Lin-Mari de Klerk-Lorist¹¹, Juan Carlos Dib¹², Maria Echavarría¹³, Giovanni Ghelmetti¹⁴, Amanda Gibson¹⁵, Maria Adelaida Gomez¹³, Wynand Goosen¹⁴, Eamonn Gormley¹⁶, Christian Gortazar¹⁷, Ana Marcia Guimarães¹⁸, Rogelio Hernandez Pando¹⁹, Nastassja Kriel¹⁴, Rajiv Kumar²⁰, Michele Miller¹⁴, Munyaradzi Musvosvi²¹, Jairo Enrique Palomares Velosa²², Christine Petersen²³, Fred Quinn²⁴, Niaina Rakotosamimanana²⁵, Samantha Sampson¹⁴, Sara Savic²⁶, Cristian Alfredo Segura-Cerda²⁷, Rachel Tanner²⁸, Begna Tulu²⁹, Bernardo Villarreal-Ramos¹⁵, Robert John Wilkinson³⁰, Cate Williams¹⁵, Samantha Vermaak³¹, Blakeley Nixon³²

Affiliations

¹ South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa. Electronic address: miller@sun.ac.za.
² Centro Internacional de Entrenamiento e Investigaciones Médicas, CIDEIM, Cali, Colombia; Universidad Icesi, Cali, Colombia.
³ Department of Biology, University of Oxford, OX1 3RB, UK.
⁴ The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
⁵ Centre of Excellence for Bovine TB, Department of Life Sciences, Aberystwyth University, Carwyn James Building, Penglais Campus, Aberystwyth, Ceredigion SY23 3FD, UK.
⁶ King Khalid University, Saudi Arabia.
⁷ INTA, Argentina.
⁸ Pasteur Institute of Tunis, Tunisia.
⁹ University of Glasgow, UK.
¹⁰ SANParks, South Africa.
¹¹ Department of Agriculture, Land Reform and Rural Development, South Africa.
¹² Fundacion Salud para el Tropico, Colombia.
¹³ CIDEIM, Colombia.
¹⁴ Stellenbosch University, South Africa.
¹⁵ University of Aberystwyth, UK.
¹⁶ University College Dublin, Ireland.
¹⁷ Universidad de Castilla La Mancha (UCLM), Spain.
¹⁸ Institute of Biomedical Sciences, University of São Paulo, Brazil.
¹⁹ Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico.
²⁰ Banaras Hindu University, India.
²¹ University of Cape Town / South African Tuberculosis Vaccine Initiative, South Africa.
²² Centro Internacional de Entrenamiento e Investigaciones Médicas - CIDEIM, Colombia.
²³ University of Iowa, USA.
²⁴ University of Georgia, USA.
²⁵ Institut Pasteur de Madagascar, Madagascar.
²⁶ Scientific Veterinary Institute Novi Sad, Serbia.
²⁷ CIATEJ, Mexico.
²⁸ University of Oxford, UK.
²⁹ Bahir Dar University, Ethiopia.
³⁰ Francis Crick Institute, Imperial College London, and the University of Cape Town, UK.
³¹ VALIDATE Co-Investigator & Executive Manager, University of Oxford, UK.
³² VALIDATE Events and Communication Coordinator, University of Oxford, UK.

PMID: 40023904
DOI: 10.1016/j.vaccine.2025.126929

Free article

Workshop report: One Health challenges and knowledge gaps in the control of intracellular infections with a focus on tuberculosis and leishmaniasis

Michele Miller et al. Vaccine. 2025.

Free article

. 2025 Apr 19:53:126929.

doi: 10.1016/j.vaccine.2025.126929. Epub 2025 Mar 1.

Authors

Michele Miller¹, Maria Adelaida Gómez², Rachel Tanner³, Samantha Vermaak⁴, Bernardo Villarreal-Ramos⁵; VALIDATE Network One Health Working Group

Collaborators

VALIDATE Network One Health Working Group:
Salem Almujri⁶, Federico Blanco⁷, Thouraya Boussoffara⁸, Richard Burchmore⁹, Peter Buss¹⁰, Lin-Mari de Klerk-Lorist¹¹, Juan Carlos Dib¹², Maria Echavarría¹³, Giovanni Ghelmetti¹⁴, Amanda Gibson¹⁵, Maria Adelaida Gomez¹³, Wynand Goosen¹⁴, Eamonn Gormley¹⁶, Christian Gortazar¹⁷, Ana Marcia Guimarães¹⁸, Rogelio Hernandez Pando¹⁹, Nastassja Kriel¹⁴, Rajiv Kumar²⁰, Michele Miller¹⁴, Munyaradzi Musvosvi²¹, Jairo Enrique Palomares Velosa²², Christine Petersen²³, Fred Quinn²⁴, Niaina Rakotosamimanana²⁵, Samantha Sampson¹⁴, Sara Savic²⁶, Cristian Alfredo Segura-Cerda²⁷, Rachel Tanner²⁸, Begna Tulu²⁹, Bernardo Villarreal-Ramos¹⁵, Robert John Wilkinson³⁰, Cate Williams¹⁵, Samantha Vermaak³¹, Blakeley Nixon³²

Affiliations

¹ South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa. Electronic address: miller@sun.ac.za.
² Centro Internacional de Entrenamiento e Investigaciones Médicas, CIDEIM, Cali, Colombia; Universidad Icesi, Cali, Colombia.
³ Department of Biology, University of Oxford, OX1 3RB, UK.
⁴ The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
⁵ Centre of Excellence for Bovine TB, Department of Life Sciences, Aberystwyth University, Carwyn James Building, Penglais Campus, Aberystwyth, Ceredigion SY23 3FD, UK.
⁶ King Khalid University, Saudi Arabia.
⁷ INTA, Argentina.
⁸ Pasteur Institute of Tunis, Tunisia.
⁹ University of Glasgow, UK.
¹⁰ SANParks, South Africa.
¹¹ Department of Agriculture, Land Reform and Rural Development, South Africa.
¹² Fundacion Salud para el Tropico, Colombia.
¹³ CIDEIM, Colombia.
¹⁴ Stellenbosch University, South Africa.
¹⁵ University of Aberystwyth, UK.
¹⁶ University College Dublin, Ireland.
¹⁷ Universidad de Castilla La Mancha (UCLM), Spain.
¹⁸ Institute of Biomedical Sciences, University of São Paulo, Brazil.
¹⁹ Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico.
²⁰ Banaras Hindu University, India.
²¹ University of Cape Town / South African Tuberculosis Vaccine Initiative, South Africa.
²² Centro Internacional de Entrenamiento e Investigaciones Médicas - CIDEIM, Colombia.
²³ University of Iowa, USA.
²⁴ University of Georgia, USA.
²⁵ Institut Pasteur de Madagascar, Madagascar.
²⁶ Scientific Veterinary Institute Novi Sad, Serbia.
²⁷ CIATEJ, Mexico.
²⁸ University of Oxford, UK.
²⁹ Bahir Dar University, Ethiopia.
³⁰ Francis Crick Institute, Imperial College London, and the University of Cape Town, UK.
³¹ VALIDATE Co-Investigator & Executive Manager, University of Oxford, UK.
³² VALIDATE Events and Communication Coordinator, University of Oxford, UK.

PMID: 40023904
DOI: 10.1016/j.vaccine.2025.126929

Abstract

The VALIDATE Network brings together scientists addressing vaccine development for neglected infectious diseases caused by intracellular pathogens. In September 2023, the first workshop on One Health approaches to research and capacity building was held in Paarl, South Africa, with a focus on tuberculosis and leishmaniasis. Thirty-two scientists from 15 countries presented and discussed broad topics pertinent to zoonotic diseases, cross-species disease transmission, disease mitigation strategies, inequitable access to medicines and health technologies, and health system challenges in One Health. In this report, we summarize the gaps, challenges, and opportunities identified during the 2023 VALIDATE One Health workshop. We anticipate that the experiences and dialogues will be informative for animal, human, and environmental health investigators to guide the development of research projects and vaccine development with a One Health vision.

Keywords: Health system challenges; Inequitable access to medicine and health technologies; Leishmaniasis; One Health; Tuberculosis; VALIDATE Network; Vaccine development; Zoonotic Diseases.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Samantha Vermaak, Blakeley Nixon reports financial support was provided by Bill and Melinda Gates Foundation (INV-031830). Rachel Tanner reports financial support was provided by Jenner Institute for Vaccine Research. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Workshop report: One Health challenges and knowledge gaps in the control of intracellular infections with a focus on tuberculosis and leishmaniasis

Collaborators

Affiliations

Workshop report: One Health challenges and knowledge gaps in the control of intracellular infections with a focus on tuberculosis and leishmaniasis

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical