Reinfection Patterns Following Two-Stage Exchange for Periprosthetic Joint Infection: A Retrospective Analysis

Abstract

Background: Periprosthetic joint infection (PJI) is a challenging complication following total joint arthroplasty. A two-stage exchange has been the gold standard in the treatment of chronic PJI. However, when this fails, further treatment options become limited. In patients who fail two-stage exchange, the reinfecting organism is different from the original in 50 to 80% of the occurrences. This study aimed to understand reinfection patterns in an attempt to better predict reinfecting organisms to improve the management of PJI.

Methods: A retrospective query of our institution's PJI registry identified 185 patients (188 procedures, 110 knees, and 78 hips) who underwent a first-time two-stage exchange for culture-positive chronic PJI of total knee and hip arthroplasties from January 2010 to December 2020. Patients who had polymicrobial infections, culture-negative results, or fungal infections were excluded. The primary outcome variable was reoperation for reinfection and comparing the index organism to the reinfecting organisms.

Results: Of the 188 procedures, 31 (16.5%) failed due to reinfection. Among reinfections, 30 (96.8%) were gram-positive, with Staphylococcus aureus species accounting for 22 (71.0%) of the cases. The most common organisms cultured were for methicillin-sensitive S. Aureus, methicillin-resistant S. Aureus, coagulase-negative staphylococcus, and streptococcus. Of reinfections, 19 (61.3%) had a different organism, eight (25.8%) had the same organism, and four (12.9%) were culture-negative. Patients experiencing reinfection were significantly younger (P = 0.012), with no other patterns or predictors identified.

Conclusions: The majority of reinfections following a two-stage exchange for PJI occur with a different organism than the index infection. We did not find a reliable method to predict the reinfecting organisms based on the initial infecting organism alone. However, the same four gram-positive organisms were the most frequently encountered in both the primary infection and the reinfection. Further research is required to understand factors contributing to reinfection and help guide prevention strategies.

Keywords: MRSA; periprosthetic joint infection; reinfection patterns; treatment failure; two-stage exchange.