Clinical features by disease duration in ulcerative colitis-associated cancers

Hiroshi Miyakita¹, Seiichiro Yamamoto¹, Motoi Uchino², Ikeuchi Hiroki², Koji Okabayashi³, Oka Shiro⁴, Kitaro Futami⁵, Michio Itabashi⁶, Kazuhiro Watanabe⁷, Masatsune Shibutani⁸, Yoshiki Okita⁹, Toshifumi Wakai¹⁰, Yusuke Mizuuchi¹¹, Kinya Okamoto¹², Kazutaka Yamada¹³, Yu Sato¹⁴, Takayuki Ogino¹⁵, Hideaki Kimura¹⁶, Kenichi Takahashi¹⁷, Koya Hida¹⁸, Yusuke Kinugasa¹⁹, Fumio Ishida²⁰, Junji Okuda²¹, Koji Daito²², Takayuki Yamamoto²³, Fumikazu Koyama²⁴, Tunekazu Hanai²⁵, Koji Komori²⁶, Dai Shida²⁷, Tatsuki Noguchi²⁸, Kenichi Sugihara²⁹, Yoichi Ajioka³⁰, Soichiro Ishihara²⁸; Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum

Affiliations

¹ Department of Surgery, Tokai University School of Medicine, Isehara, Japan.
² Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
³ Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
⁴ Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
⁵ Department of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
⁶ Division of Inflammatory Bowel Disease Surgery, Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan.
⁷ Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
⁸ Department of Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
⁹ Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.
¹⁰ Division of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
¹¹ Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹² Department of Coloproctology, Tokyo Yamate Medical Center, Tokyo, Japan.
¹³ Department of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.
¹⁴ Department of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
¹⁵ Department of Gastroenterological Surgery, Graduate School of Medical, Osaka University, Osaka, Japan.
¹⁶ Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
¹⁷ Department of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan.
¹⁸ Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
¹⁹ Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
²⁰ Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
²¹ Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
²² Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
²³ Inflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Japan.
²⁴ Department of Surgery, Nara Medical University, Kashihara, Japan.
²⁵ Department of Surgery, School of Medicine, Fujita Health University, Toyoake, Japan.
²⁶ Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
²⁷ Division of Frontier Surgery, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
²⁸ Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
²⁹ Tokyo Medical and Dental University, Tokyo, Japan.
³⁰ Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

PMID: 40025818
DOI: 10.1111/codi.70044

Clinical features by disease duration in ulcerative colitis-associated cancers

Hiroshi Miyakita et al. Colorectal Dis. 2025 Mar.

. 2025 Mar;27(3):e70044.

doi: 10.1111/codi.70044.

Authors

Affiliations

¹ Department of Surgery, Tokai University School of Medicine, Isehara, Japan.
² Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
³ Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
⁴ Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
⁵ Department of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
⁶ Division of Inflammatory Bowel Disease Surgery, Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan.
⁷ Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
⁸ Department of Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
⁹ Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.
¹⁰ Division of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
¹¹ Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹² Department of Coloproctology, Tokyo Yamate Medical Center, Tokyo, Japan.
¹³ Department of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.
¹⁴ Department of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
¹⁵ Department of Gastroenterological Surgery, Graduate School of Medical, Osaka University, Osaka, Japan.
¹⁶ Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
¹⁷ Department of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan.
¹⁸ Department of Surgery, Kyoto University Hospital, Kyoto, Japan.
¹⁹ Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
²⁰ Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
²¹ Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
²² Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
²³ Inflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Japan.
²⁴ Department of Surgery, Nara Medical University, Kashihara, Japan.
²⁵ Department of Surgery, School of Medicine, Fujita Health University, Toyoake, Japan.
²⁶ Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
²⁷ Division of Frontier Surgery, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
²⁸ Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
²⁹ Tokyo Medical and Dental University, Tokyo, Japan.
³⁰ Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

PMID: 40025818
DOI: 10.1111/codi.70044

Abstract

Aim: Ulcerative colitis (UC) is a known contributor to the development of colitis-associated cancer (CAC), although the exact mechanism remains to be elucidated. CAC typically presents as a flat type macroscopically and manifests histologically as mucinous carcinoma and signet ring cell carcinoma. While the relationship between disease duration and chronic inflammation has been studied, the impact of disease duration on CAC outcomes has yet to be thoroughly investigated. The aim of this study is to examine the effect of UC duration on the clinicopathological features of CAC.

Method: This study analysed data from the Japan Society for Colorectal Cancer Research involving UC patients diagnosed with colorectal cancer. The sample consisted of 1200 patients, and their histological and clinicopathological features were analysed. Cutoff values were established at 5 and 15 years for comparisons. Trends and prognostic outcomes corresponding to disease duration were evaluated.

Results: Comparison between two groups (disease duration 0-5 and >5 years) revealed a significant correlation in terms of diagnostic opportunity, vascular invasion, N factor, pathological stage and tumour location. However, between the two groups of 0-15 and >15 years, a significant correlation was identified only in diagnostic opportunity, the presence of primary sclerosing cholangitis. Trend analysis of disease duration showed significant correlations between diagnostic opportunity, histological type, vascular invasion and tumour location, with no significant differences observed in prognostic outcomes.

Conclusion: Our analysis highlighted distinct histological and clinical features in the short-term and long-term disease groups, and these features appear to intensify with increased disease duration. Since no significant difference in prognosis was found, there may not be a need to distinguish between them in cancer treatment.

Keywords: colitis‐associated cancer; disease duration; ulcerative colitis.

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References

REFERENCES

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Clinical features by disease duration in ulcerative colitis-associated cancers

Affiliations

Clinical features by disease duration in ulcerative colitis-associated cancers

Authors

Affiliations

Abstract

References

REFERENCES

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical