Development and implementation of the international AIDA network spondylarthritis registry

Valeria Caggiano^#^{1

2}, Antonio Vitale^#^{1

2}, Andrea Hinojosa-Azaola³, Guillermo Arturo Guaracha-Basañez³, Piero Ruscitti⁴, Paola Cipriani⁴, Samar Tharwat^{5

6}, Hanan M Elberashi⁵, Esraa E Othman⁵, Alessandro Conforti⁷, Giancarlo Gimignani⁷, Sukran Erten⁸, Patrizia Barone⁹, Maissa Thabet¹⁰, Jurgen Sota^{1

2}, José Hernández-Rodríguez¹¹, Verónica Gómez-Caverzaschi¹¹, Gaafar Ragab^{12

13}, Amina Maher¹², Ezgi Deniz Batu¹⁴, Perla Ayumi Kawakami-Campos¹⁵, Jiram Torres-Ruiz³, Carla Gaggiano^{1

2}, Abdurrahman Tufan¹⁶, Hamit Kucuk¹⁶, Henrique A Mayrink Giardini¹⁷, Guiga Ahmed¹⁰, Mehmet Akif Eksin¹⁸, Lampros Fotis¹⁹, Azadeh Shariat Panahi⁴, Stefano Gentileschi^{1

2}, Ibrahim A Almaghlouth^{20

21}, Petros P Sfikakis²², George E Fragoulis²², Costanza Monterosso²³, Daniela Opris-Belinski²⁴, Soad Hashad²⁵, Nunzia Di Meglio^{2

26}, Cristian Sica^{2

26}, Bahar Özdemir Ulusoy¹⁸, Alejandra de-la-Torre²⁷, Ewa Wiesik-Szewczyk²⁸, Katarzyna Rybak²⁸, Alberto Balistreri^{2

29}, Claudia Fabiani^{2

30}, Maria Antonietta Mazzei^{2

26}, Bruno Frediani^{1

2}, Luca Cantarini^{1

2}

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
² Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy.
³ Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
⁴ Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
⁵ Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt.
⁶ Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt.
⁷ Ospedale San Paolo di Civitavecchia, U.O. Medicina Generale, Rome, Italy.
⁸ Department of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
⁹ Pediatric Rheumatology Unit, Department of Integrated Maternal-Child and Reproduction Activity AOU "Policlinico-San Marco", Catania, Italy.
¹⁰ Internal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
¹¹ Clinical Unit of Autoinflammatory Diseases, Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
¹² Rheumatology and Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
¹³ Faculty of Medicine, Newgiza University, 6th of October City, Egypt.
¹⁴ Department of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
¹⁵ Department of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
¹⁶ Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Türkiye.
¹⁷ Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
¹⁸ Clinic of Rheumatology, Ankara Gaziler Physical Therapy and Rehabilitation Training and Research Hospital, Ankara, Türkiye.
¹⁹ Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
²⁰ Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
²¹ College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
²² Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
²³ Department of Rheumatology, Università Vita-Salute San Raffaele, Milan, Italy.
²⁴ Rheumatology and Internal Medicine Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
²⁵ Rheumatology Department Tripoli Children Hospital, Tripoli, Libya.
²⁶ Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, Siena, Italy.
²⁷ Neuroscience Research Group (NEUROS), NeuroVitae Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
²⁸ Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, Military Institute of Medicine, National Research Institute, Warsaw, Poland.
²⁹ Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
³⁰ Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

^# Contributed equally.

PMID: 40027889
PMCID: PMC11868044
DOI: 10.3389/fmed.2025.1509357

Development and implementation of the international AIDA network spondylarthritis registry

Valeria Caggiano et al. Front Med (Lausanne). 2025.

. 2025 Feb 14:12:1509357.

doi: 10.3389/fmed.2025.1509357. eCollection 2025.

Authors

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
² Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy.
³ Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
⁴ Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
⁵ Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt.
⁶ Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt.
⁷ Ospedale San Paolo di Civitavecchia, U.O. Medicina Generale, Rome, Italy.
⁸ Department of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
⁹ Pediatric Rheumatology Unit, Department of Integrated Maternal-Child and Reproduction Activity AOU "Policlinico-San Marco", Catania, Italy.
¹⁰ Internal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
¹¹ Clinical Unit of Autoinflammatory Diseases, Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
¹² Rheumatology and Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
¹³ Faculty of Medicine, Newgiza University, 6th of October City, Egypt.
¹⁴ Department of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
¹⁵ Department of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
¹⁶ Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Türkiye.
¹⁷ Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
¹⁸ Clinic of Rheumatology, Ankara Gaziler Physical Therapy and Rehabilitation Training and Research Hospital, Ankara, Türkiye.
¹⁹ Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
²⁰ Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
²¹ College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
²² Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
²³ Department of Rheumatology, Università Vita-Salute San Raffaele, Milan, Italy.
²⁴ Rheumatology and Internal Medicine Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
²⁵ Rheumatology Department Tripoli Children Hospital, Tripoli, Libya.
²⁶ Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, Siena, Italy.
²⁷ Neuroscience Research Group (NEUROS), NeuroVitae Center, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
²⁸ Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, Military Institute of Medicine, National Research Institute, Warsaw, Poland.
²⁹ Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
³⁰ Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

^# Contributed equally.

PMID: 40027889
PMCID: PMC11868044
DOI: 10.3389/fmed.2025.1509357

Abstract

During the last decade, spondyloarthritis (SpA) has increasingly been considered a disease at the crossroads between autoimmunity and autoinflammation. Some patients may even present with autoinflammatory-related manifestations, including fever, hidradenitis suppurativa, other neutrophilic dermatoses, and an unusually high increase in inflammatory markers. Therefore, a subgroup of SpA patients may be identified, and specific details about this cluster need to be investigated. In this regard, the AutoInflammatory Disease Alliance (AIDA) Network has developed a registry primarily aimed at better understanding the autoinflammatory aspects of SpA. The development of this Registry favors the systematic assessment of SpA through the lens of autoinflammation, giving a voice to patients with atypical presentations, and favoring a personalized treatment approach. By supporting research and facilitating the transfer of new evidence to clinical practice, this specific registry has the potential to significantly advance the field of rheumatology and enhance the lives of patients suffering from this complex and multifaceted disease.

Keywords: autoinflamatory diseases; prognostic factor; real life; register; spondylarthritis; treatment.

Copyright © 2025 Caggiano, Vitale, Hinojosa-Azaola, Guaracha-Basañez, Ruscitti, Cipriani, Tharwat, Elberashi, Othman, Conforti, Gimignani, Erten, Barone, Thabet, Sota, Hernández-Rodríguez, Gómez-Caverzaschi, Ragab, Maher, Batu, Kawakami-Campos, Torres-Ruiz, Gaggiano, Tufan, Kucuk, Mayrink Giardini, Ahmed, Eksin, Fotis, Panahi, Gentileschi, Almaghlouth, Sfikakis, Fragoulis, Monterosso, Opris-Belinski, Hashad, Di Meglio, Sica, Ulusoy, de-la-Torre, Wiesik-Szewczyk, Rybak, Balistreri, Fabiani, Mazzei, Frediani and Cantarini.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

**Figure 1**
The map illustrates the global distribution of the autoinflammatory disease alliance (AIDA) network as of October 2024.

See this image and copyright information in PMC

References

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Development and implementation of the international AIDA network spondylarthritis registry

Affiliations

Development and implementation of the international AIDA network spondylarthritis registry

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources