Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Feb 18;16(2):100745.
doi: 10.5312/wjo.v16.i2.100745.

Individual and population differences affect the pain management in acute musculoskeletal injury

Affiliations
Editorial

Individual and population differences affect the pain management in acute musculoskeletal injury

Yu Deng et al. World J Orthop. .

Abstract

In this editorial, we comment on the article published in a recent issue of the World Journal of Orthopedics. Although substantial literature regarding pain management of acute musculoskeletal injury has been published over the last three decades, there is still a lack of evidence-based protocol for individual and population disparities. This systematic review gives us a comprehensive view of the evidence-based use of opioid vs opioid-free analgesia. Nevertheless, there is still a need for further investigation at a high level regarding this topic.

Keywords: Acute musculoskeletal injury; Acute traumatic pain; Non-opioid analgesia; Non-opioid pain control; Opioid crisis; Opioid-sparing analgesia.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

References

    1. Rosenberg K. Opioid and Nonopioid Analgesics Provide Similar Relief From Acute Extremity Pain. Am J Nurs. 2018;118:69–70. - PubMed
    1. Fabbri A, Voza A, Riccardi A, Serra S, Iaco F Study and Research Center of the Italian Society of Emergency Medicine (SIMEU) The Pain Management of Trauma Patients in the Emergency Department. J Clin Med. 2023;12:3289. - PMC - PubMed
    1. Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial. JAMA. 2017;318:1661–1667. - PMC - PubMed
    1. Fiore M, Nasto LA, McCaffery E, Barletta F, Visconti A, Gargano F, Pola E, Pace MC. Pain management in acute musculoskeletal injury: Effect of opioid vs nonopioid medications. World J Orthop. 2024;15:882–890. - PMC - PubMed
    1. Jalili M, Mozaffarpour Noori A, Sedaghat M, Safaie A. Efficacy of Intravenous Paracetamol Versus Intravenous Morphine in Acute Limb Trauma. Trauma Mon. 2016;21:e19649. - PMC - PubMed

Publication types

LinkOut - more resources