[Treatment of the unstable bladder in children with the anticholinergic agent propiverin hydrochloride (mictonorm/mictonets)]

Abstract

The new anticholinergic agent Propiverinhydrochlorid (Mictonorm) is used in the treatment of the Enuresis nocturna et diurna combined with urgency, frequency and small amounts of voided urine. The urodynamic investigation shows an unstable bladder. No urinary tract obstruction or neurogenic injuries are detected at the 26 normal-developed children of 5-11 years of age. Mictonorm was given for 3 months, in a dosage of 0,4 mg/kg bw/d. The bladder capacity, the volume at the desire to void and the compliance of the detrusor significantly increased and the frequency decreased. Application of placebo shows no variation of these parameters. No side-effects were to be distinguish. The wetting improved significantly in 16 of the 26 children but dryness seldom was reached. Therefore the dose was doubled in 19 children at the fourth month, and a second equal group of 26 children primary was treated with 0,7-0,8 mg/kg bw/d. With good compatibility especially the higher dose given from the beginning improved the enuresis better. All children showed a more distinct influence to the enuresis diurna than to the nocturna. The prescription of the anticholinergic neurotrope and myotrope drug is interpreted as a part of the management of the wetting child and its environment.