SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Gregory J Walker¹, Kylie-Ann Mallitt², Maria E Craig³, Pat Ashwood⁴, Simon C Barry⁴, James D Brown⁴, Joanna Caguicla¹, Elizabeth A Davis⁵, Emma E Hamilton-Williams⁶, Leonard C Harrison⁷, Aveni Haynes⁵, Tony Huynh⁸, Guinevere Martin⁴, Kelly J McGorm⁴, Grant Morahan⁹, Zin Naing¹, Helena Oakey⁴, Megan A S Penno⁴, Andrea Sevendal¹, Richard O Sinnott¹⁰, Georgia Soldatos¹¹, Rebecca L Thomson⁴, Jason Tye-Din⁷, Peter J Vuillermin¹², Emily J Ward¹, John M Wentworth⁷, Peter G Colman¹³, Jennifer J Couper⁴, Ki Wook Kim¹⁴, William D Rawlinson¹; ENDIA Study Group

Collaborators, Affiliations

Collaborators

ENDIA Study Group:
Fergus Cameron N/A, Andrew Day N/A, Prudence Lopez N/A, Amanda J Anderson N/A, William Hu N/A, Dao Huynh N/A, Kelly Watson N/A, Sarah Beresford N/A, Deborah Bezuidenhout N/A, Susan Brandrick N/A, Carlie Butterworth N/A, Jacki Catteau N/A, Helen Griffiths N/A, Alison Gwiazdzinski N/A, Candice Hall N/A, Amanda Hulley N/A, Lee Henneken N/A, Renee Kludas N/A, Ying Mateevici N/A, Benjamin Ramoso N/A, Alison Roberts N/A, Alexandra Tully N/A, Rosemary Wood N/A, Sabrina Binkowski N/A, Minh Bui N/A, Abbey Gilbert N/A, Dexing Huang N/A, Ana Karceva N/A, Brydie-Rose Mellor N/A, Gaetano Neselli N/A, Katrina Ngui N/A, Trung Nguyen N/A, Bina Patel N/A, Vanessa Prajitno N/A, Natalie Stone N/A, Thao Tran N/A, Sapphire Vaega N/A, Yan Xu N/A, Cynthia Yau N/A, Rachel Battersby N/A, Bek Brittain N/A, Charles Foster N/A, Christopher Hope N/A, Preston Leung N/A, Alexandra Roth-Schulze N/A, Tim Sadlon N/A, Bree Tillett N/A, Ying Y Wong N/A, Enrique Zozaya-Valdes N/A, Leanne Cavenett N/A

Affiliations

¹ Virology Research Laboratory, University of New South Wales School of Biomedical Sciences and New South Wales Health Pathology, Sydney, New South Wales, Australia.
² Sydney School of Public Health, University of Sydney, New South Wales, Australia.
³ Discipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
⁴ Adelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
⁵ Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia.
⁶ Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia.
⁷ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁸ Department of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
⁹ Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
¹⁰ Melbourne eResearch Group, School of Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia.
¹¹ School of Public Health and Preventive Medicine and School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
¹² Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia.
¹³ Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
¹⁴ School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.

PMID: 40029632
PMCID: PMC11877402
DOI: 10.1001/jamapediatrics.2024.6848

SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Gregory J Walker et al. JAMA Pediatr. 2025.

. 2025 May 1;179(5):568-570.

doi: 10.1001/jamapediatrics.2024.6848.

Authors

Collaborators

ENDIA Study Group:
Fergus Cameron N/A, Andrew Day N/A, Prudence Lopez N/A, Amanda J Anderson N/A, William Hu N/A, Dao Huynh N/A, Kelly Watson N/A, Sarah Beresford N/A, Deborah Bezuidenhout N/A, Susan Brandrick N/A, Carlie Butterworth N/A, Jacki Catteau N/A, Helen Griffiths N/A, Alison Gwiazdzinski N/A, Candice Hall N/A, Amanda Hulley N/A, Lee Henneken N/A, Renee Kludas N/A, Ying Mateevici N/A, Benjamin Ramoso N/A, Alison Roberts N/A, Alexandra Tully N/A, Rosemary Wood N/A, Sabrina Binkowski N/A, Minh Bui N/A, Abbey Gilbert N/A, Dexing Huang N/A, Ana Karceva N/A, Brydie-Rose Mellor N/A, Gaetano Neselli N/A, Katrina Ngui N/A, Trung Nguyen N/A, Bina Patel N/A, Vanessa Prajitno N/A, Natalie Stone N/A, Thao Tran N/A, Sapphire Vaega N/A, Yan Xu N/A, Cynthia Yau N/A, Rachel Battersby N/A, Bek Brittain N/A, Charles Foster N/A, Christopher Hope N/A, Preston Leung N/A, Alexandra Roth-Schulze N/A, Tim Sadlon N/A, Bree Tillett N/A, Ying Y Wong N/A, Enrique Zozaya-Valdes N/A, Leanne Cavenett N/A

Affiliations

¹ Virology Research Laboratory, University of New South Wales School of Biomedical Sciences and New South Wales Health Pathology, Sydney, New South Wales, Australia.
² Sydney School of Public Health, University of Sydney, New South Wales, Australia.
³ Discipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
⁴ Adelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
⁵ Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia.
⁶ Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia.
⁷ Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁸ Department of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
⁹ Centre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
¹⁰ Melbourne eResearch Group, School of Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia.
¹¹ School of Public Health and Preventive Medicine and School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
¹² Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia.
¹³ Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
¹⁴ School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.

PMID: 40029632
PMCID: PMC11877402
DOI: 10.1001/jamapediatrics.2024.6848

No abstract available

Plain language summary

This cohort study examines whether there is a temporal association between SARS-CoV-2 infection and the development of islet autoimmunity among Australian children with a first-degree relative with type 1 diabetes.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

See this image and copyright information in PMC

References

1. Unsworth R, Wallace S, Oliver NS, et al. . New-onset type 1 diabetes in children during COVID-19: multicenter regional findings in the U.K. Diabetes Care. 2020;43(11):e170-e171. doi:10.2337/dc20-1551 - DOI - PubMed
1. Lugar M, Eugster A, Achenbach P, et al. ; GPPAD Study Group . SARS-CoV-2 infection and development of islet autoimmunity in early childhood. JAMA. 2023;330(12):1151-1160. doi:10.1001/jama.2023.16348 - DOI - PMC - PubMed
1. Krischer JP, Lernmark Å, Hagopian WA, et al. ; TEDDY Study Group . SARS-CoV-2 - no increased islet autoimmunity or type 1 diabetes in teens. N Engl J Med. 2023;389(5):474-475. doi:10.1056/NEJMc2216477 - DOI - PMC - PubMed
1. Friedl N, Sporreiter M, Winkler C, et al. ; Fr1da Study Group . Progression from presymptomatic to clinical type 1 diabetes after COVID-19 infection. JAMA. 2024;332(6):501-502. doi:10.1001/jama.2024.11174 - DOI - PMC - PubMed
1. Penno MAS, Couper JJ, Craig ME, et al. ; ENDIA Study Group . Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatr. 2013;13(1):124. doi:10.1186/1471-2431-13-124 - DOI - PMC - PubMed

LinkOut - more resources

Full Text Sources
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Collaborators

Affiliations

SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Authors

Collaborators

Affiliations

Plain language summary

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources

Miscellaneous