The role of transferrin and ferritin in the fetal-maternal-placental unit

Abstract

The rapidly growing human fetus requires a large supply of iron, which is obtained from the iron stores of the mother. Iron is transported from mother to fetus against a concentration gradient. The placenta plays a key role in regulating the supply of iron in the fetus. In both anemic and nonanemic patients serum ferritin levels decreased and total iron-binding capacity increased as gestation progressed. The total iron-binding capacity is higher in maternal than in umbilical cord blood at delivery; this suggests that little or no ferritin or transferrin is transferred from mother to fetus. Mother and fetus appear to have independent systems controlling iron metabolism. Transferrin was localized on the site facing the intervillous space, on the surface of the microvilli of the syncytiotrophoblasts. The removal of transferrin from the surface of the trophoblast by thiocyanate and its rebinding were demonstrated. Ferritin was shown to be present in all layers of the trophoblast and especially in the syncytiotrophoblast.